{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T12:44:45Z","timestamp":1782996285928,"version":"3.54.5"},"reference-count":10,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["World J Pediatr Congenit Heart Surg"],"abstract":"\n Objectives<\/jats:title>\n \n Extracorporeal Membrane Oxygenation (ECMO) is associated with high risks of bleeding and clotting. While traditional anticoagulants like heparin and bivalirudin target the coagulation cascade, prostaglandins including PGE\n 1<\/jats:sub>\n and PGI\n 2<\/jats:sub>\n may offer adjunctive platelet inhibition. This study evaluated whether prostaglandin use modifies the risk of severe bleeding or clotting events in pediatric ECMO patients.\n <\/jats:p>\n <\/jats:sec>\n \n Material and Methods<\/jats:title>\n We used the Pediatric Health Information System database from 2004 to 2025, and included children supported with ECMO. Primary outcomes were severe bleeding and clotting events. Generalized linear mixed model regressions adjusted for site, patient and ECMO data, and pulmonary hypertension.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n A total of 22,061 pediatric ECMO patients were included. Pulmonary hypertension was present in 12.4% (2736\/22,061). PGE\n 1<\/jats:sub>\n and PGI\n 2<\/jats:sub>\n were independently associated with increased risk of pulmonary hemorrhage (PGE\n 1<\/jats:sub>\n : adjusted OR 1.24,\n P<\/jats:italic>\n \u2009=\u2009.003; PGI\n 2<\/jats:sub>\n : adjusted OR 1.21,\n P<\/jats:italic>\n \u2009=\u2009.047). Conversely, neither PGE\n 1<\/jats:sub>\n nor PGI\n 2<\/jats:sub>\n were independently associated with intracranial hemorrhage (PGE\n 1<\/jats:sub>\n : adjusted OR 1.01,\n P<\/jats:italic>\n \u2009=\u2009.92; PGI\n 2<\/jats:sub>\n : adjusted OR 0.96,\n P<\/jats:italic>\n \u2009=\u2009.79), stroke (PGE\n 1<\/jats:sub>\n : adjusted OR 1.02,\n P<\/jats:italic>\n \u2009=\u2009.84; PGI\n 2<\/jats:sub>\n : adjusted OR 0.88,\n P<\/jats:italic>\n \u2009=\u2009.38), or other bleeding or thrombotic events.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n In this large multicenter cohort of more than 22,000 pediatric ECMO patients, neither PGE\n 1<\/jats:sub>\n nor PGI\n 2<\/jats:sub>\n -modulated anticoagulation conferred measurable protection against the major bleeding or clotting complications.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/21501351261453052","type":"journal-article","created":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T13:15:18Z","timestamp":1782738918000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Prostaglandin Administration and Outcomes in Children on Extracorporeal Membrane Oxygenation"],"prefix":"10.1177","author":[{"given":"Weidi","family":"Xiao","sequence":"first","affiliation":[{"name":"Yale"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nedaa","family":"Aldairi","sequence":"additional","affiliation":[{"name":"Dr Sulaiman AlHabib Medical Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian S.","family":"Marcus","sequence":"additional","affiliation":[{"name":"Albert Einstein College of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Weiss","sequence":"additional","affiliation":[{"name":"Centre M\u00e8re-Enfant Soleil du CHU de Qu\u00e9bec, Quebec"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison S.","family":"Cowl","sequence":"additional","affiliation":[{"name":"Connecticut Children\u2019s Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marissa","family":"Moncata","sequence":"additional","affiliation":[{"name":"Yale New Haven Children's Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akash","family":"Deep","sequence":"additional","affiliation":[{"name":"King's College Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6606-1736","authenticated-orcid":false,"given":"Oliver","family":"Karam","sequence":"additional","affiliation":[{"name":"Yale School of Medicine, Yale"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,6,29]]},"reference":[{"key":"e_1_3_2_2_2","unstructured":"Extracorporeal Life Support Organization. ELSO registry international summary 2025. Accessed June 15 2026. https:\/\/www.elso.org."},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000000317"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000003968"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000002696"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/MOP.0000000000001247"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.3389\/med.2018.00352"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21239020"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40264-015-0365-x"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.39967"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202110-2359OC"}],"container-title":["World Journal for Pediatric and Congenital Heart Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/21501351261453052","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/21501351261453052","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/21501351261453052","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T11:53:19Z","timestamp":1782993199000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/21501351261453052"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,29]]},"references-count":10,"alternative-id":["10.1177\/21501351261453052"],"URL":"https:\/\/doi.org\/10.1177\/21501351261453052","relation":{},"ISSN":["2150-1351","2150-136X"],"issn-type":[{"value":"2150-1351","type":"print"},{"value":"2150-136X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,29]]},"article-number":"21501351261453052"}}