{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T18:09:38Z","timestamp":1789063778521,"version":"build-2803163510"},"reference-count":36,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["World J Pediatr Congenit Heart Surg"],"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>To assess international practice patterns for prostaglandin E1 (PGE1) initiation and dosing in neonates with dextro-transposition of the great arteries (d-TGA) and to evaluate whether these practices differ by clinical specialty.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      We conducted an international, cross-sectional, web-based survey of neonatologists and pediatric cardiac intensivists involved in stabilizing neonates with d-TGA. The survey assessed strategies for routine versus selective PGE1 initiation, oxygen saturation thresholds, starting dose, and maximum dose policies. The primary outcome was self-reported routine PGE1 initiation. Categorical variables were compared using \u03c7\n                      <jats:sup>2<\/jats:sup>\n                      tests, and multivariable logistic regression analysis identified independent predictors of routine initiation, adjusting for specialty, region, experience, cardiology availability, institutional protocols, and sex.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      A total of 526 clinicians responded (282 neonatologists and 244 intensivists; 65.8% response rate). Neonatologists more frequently reported routine PGE1 initiation than cardiac intensivists (84.0% vs 58.6%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.001). Starting dose selection differed by specialty (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.001), whereas oxygen saturation thresholds did not (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.436). In adjusted analysis, cardiac intensivists were less likely than neonatologists to report routine initiation (adjusted OR 0.15, 95% CI 0.05-0.45).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Substantial specialty-based variation exists in PGE1 initiation and dosing for neonatal d-TGA stabilization. Because both routine and selective strategies have plausible physiologic rationale, this heterogeneity should be interpreted as hypothesis-generating, identifying the interspecialty divide as a priority target for prospective, outcome-linked comparative-effectiveness research that should precede any consensus recommendation. Limitations include the survey design, collinearity between specialty and care setting, and lack of patient-level outcome data.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/21501351261472476","type":"journal-article","created":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T17:32:22Z","timestamp":1788888742000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Specialty-Based Variation in Prostaglandin E1 Use for Neonates With dextro-Transposition of the Great Arteries: An International Cross-Sectional Survey of Neonatologists and Pediatric Cardiac Intensivists"],"prefix":"10.1177","author":[{"given":"Sharon","family":"Morag","sequence":"first","affiliation":[{"name":"Tel Aviv Sourasky Medical Center"},{"name":"Tel Aviv University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Lowenthal","sequence":"additional","affiliation":[{"name":"Tel Aviv University"},{"name":"Pediatric Cardiology, Dana Dwek Children's Hospital, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiba","family":"Abuelhija","sequence":"additional","affiliation":[{"name":"Great Ormond Street Hospital for Children NHS Foundation Trust"},{"name":"Section of Pediatric Critical Care, Hadassah University Medical Center, Jerusalem, Israel"},{"name":"Faculty of Medicine, The Hebrew University of Jerusalem"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4575-3888","authenticated-orcid":false,"given":"Uri","family":"Pollak","sequence":"additional","affiliation":[{"name":"Section of Pediatric Critical Care, Hadassah University Medical Center, Jerusalem, Israel"},{"name":"Faculty of Medicine, The Hebrew University of 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