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The purpose of this article is to summarize the proceedings of the CHSS CRQ Fall 2025 Work Weekend and to provide a 2025 Annual Report of the CHSS CRQ. At the CHSS CRQ Fall 2025 Work Weekend, multiple topics were discussed related to ongoing CHSS research and quality initiatives. The CHSS CRQ is evolving to keep pace with the rapid evolution of medical informatics and the ever-evolving regulatory issues of clinical research. This 2025 Annual Report of the CHSS CRQ summarizes some of the ongoing initiatives at CHSS CRQ designed to assure that the CHSS CRQ continues to lead innovative and collaborative clinical research to improve pediatric and congenital cardiac care.<\/jats:p>","DOI":"10.1177\/21501351261477040","type":"journal-article","created":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T07:39:43Z","timestamp":1792049983000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["The Congenital Heart Surgeons\u2019 Society Center for Research and Quality 2025 Annual Report"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9916-929X","authenticated-orcid":false,"given":"Jeffrey Phillip","family":"Jacobs","sequence":"first","affiliation":[{"name":"University of Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6254-225X","authenticated-orcid":false,"given":"William M.","family":"DeCampli","sequence":"additional","affiliation":[{"name":"Arnold Palmer Hospital for Children"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hani K.","family":"Najm","sequence":"additional","affiliation":[{"name":"Cleveland Clinic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6373-0532","authenticated-orcid":false,"given":"Osami","family":"Honjo","sequence":"additional","affiliation":[{"name":"The Hospital for Sick Children"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6353-7874","authenticated-orcid":false,"given":"Bahaaldin","family":"Alsoufi","sequence":"additional","affiliation":[{"name":"Norton Children's Hospital, University of Louisville"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tara","family":"Karamlou","sequence":"additional","affiliation":[{"name":"The University of Cincinnati College of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7586-7526","authenticated-orcid":false,"given":"Anusha","family":"Jegatheeswaran","sequence":"additional","affiliation":[{"name":"Great Ormond Street Hospital for Children"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7389-359X","authenticated-orcid":false,"given":"James D.","family":"St Louis","sequence":"additional","affiliation":[{"name":"Augusta University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8572-9874","authenticated-orcid":false,"given":"Linda M.","family":"Lambert","sequence":"additional","affiliation":[{"name":"Primary Children's Medical Center, Salt Lake City, UT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9419-7681","authenticated-orcid":false,"given":"Cedric","family":"Manlhiot","sequence":"additional","affiliation":[{"name":"The Hospital for Sick Children"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1487-4203","authenticated-orcid":false,"given":"S. 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