{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T12:55:34Z","timestamp":1780059334802,"version":"3.54.0"},"reference-count":19,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Allergy, Immunology, and Pulmonology"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Children with intestinal failure who are receiving parenteral nutrition through a central venous catheter are at risk of developing catheter-related bloodstream infections. For many years, a prophylactic lock with taurolidine has been used to decrease the incidence of these infections and is considered safe in children.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Presentation:<\/jats:title>\n                    <jats:p>A 1-month-old boy with jejunal atresia was receiving parenteral nutrition through a central venous catheter. Shortly after administration of taurolidine (TauroSept\u00ae), he developed circulatory insufficiency and angioedema. His serum tryptase increased, which was suggestive of anaphylaxis (baseline tryptase 6.3 \u00b5g\/L; 2 h after start of the reaction: 21 \u00b5g\/L; cutoff criterion for clinically relevant increase: 1.2 \u00d7 baseline tryptase level + 2).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>To the best of our knowledge, this is the first case of anaphylaxis in response to TauroSept\u00ae in an infant worldwide. Clinicians should be aware of this possible but very rare side effect.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/2151321x251379008","type":"journal-article","created":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T15:23:18Z","timestamp":1757604198000},"page":"141-143","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["TauroSept-Induced Anaphylaxis: A Pediatric Case Report"],"prefix":"10.1177","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9401-5083","authenticated-orcid":false,"given":"Elise","family":"Mank","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Emma Children\u2019s Hospital, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"Broos","sequence":"additional","affiliation":[{"name":"Department of Pediatric Allergology, Emma Children\u2019s Hospital, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid","family":"Terreehorst","sequence":"additional","affiliation":[{"name":"Department of ENT, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia","family":"Liem","sequence":"additional","affiliation":[{"name":"Department of Pediatric Allergology, Emma Children\u2019s Hospital, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte M.","family":"Nusman","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Emma Children\u2019s Hospital, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Loes E.","family":"Gerards","sequence":"additional","affiliation":[{"name":"Department of Hospital Pharmacy, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joep P.M.","family":"Derikx","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Emma Children\u2019s Hospital, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merit M.","family":"Tabbers","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology, Hepatology and Nutrition, Emma Children\u2019s Hospital, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands."},{"name":"Amsterdam Reproduction and Development and Amsterdam Gastroenterology Endocrinology Metabolism Research Institutes, Amsterdam, the Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,1,18]]},"reference":[{"key":"e_1_3_2_2_2","unstructured":"Geistlich Pharma. 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