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This preregistered study investigated artificial intelligence (AI)-assisted art therapy, utilizing ChatGPT-4, to reduce anxiety and PTSD symptoms and improve emotional well-being in 113 participants recovering from work-related injuries, compared to traditional art therapy. The AI-assisted group received personalized feedback via an AI platform analyzing artwork. Results showed significantly greater reductions in anxiety and PTSD symptoms in the AI-assisted group (moderate effect sizes, Cohen\u2019s d = 0.55 and 0.62, respectively), but no significant difference in positive affect. Qualitative interviews revealed perceived emotional support from AI, enhancing engagement. 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