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Guided by the conceptual framework of the allostatic load model, this study investigated the impact of communication overload\u2014the feeling of receiving more social input than one can manage, as commonly experienced in social media use\u2014on physical health, with social media fatigue and depressive symptoms as serial mediators. A national quota sample of 1625 adults in South Korea completed an online survey measuring communication overload associated with social media use, social media fatigue, depressive symptoms, and self-rated physical health, along with relevant demographic and behavioral covariates. Results revealed a significant indirect pathway from communication overload to physical health, sequentially through both social media fatigue and depressive symptoms. Our findings indicated that the strain of social demands associated with social media use may contribute to deterioration in both mental and physical health. 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