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Conventional methods such as surgery, hormone therapy, and assisted reproductive technologies can be successful in some cases, but are limited by adverse effects, and limited effectiveness. In recent years, cell therapy has provided new possibilities for treating various infertility disorders. The articles extracted from PubMed and Scopus databases were based on cell therapy premature ovarian failure (POF), intrauterine adhesions, Asherman syndrome (AS), recurrent implantation failure (RIF), repeat implantation failure, polycystic ovary syndrome (PCOS), endometriosis, preeclampsia, and clinical trials. The collected articles were added to EndNote X7, and review articles along with duplicate studies were eliminated. Several studies have indicated that peripheral blood mononuclear cells, autologous platelet-rich plasma, mesenchymal stem cells (MSCs), hematopoietic stem cells (HSCs), adipose-derived stromal vascular fraction, and umbilical cord stem cells can be used to treat reproductive diseases, including POF, AS, and RIF. PCOS, endometriosis, and preeclampsia were deleted from the study, because there were no clinical cell therapy studies for these diseases. Among the 210 studies, 28 were selected as eligible for further evaluation. Various clinical trials have supported the role of cell therapy in treating reproductive disorders. Although the information from this systematic review is promising, further studies are needed to evaluate the efficacy and safety of these and other cells in treating infertility.<\/jats:p>","DOI":"10.1177\/21524971251379699","type":"journal-article","created":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T17:26:20Z","timestamp":1758648380000},"page":"184-198","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Clinical Application of Cell Therapy in the Treatment of Female Reproductive Diseases: A Systematic Review"],"prefix":"10.1177","volume":"27","author":[{"given":"Fatemeh","family":"Saberi","sequence":"first","affiliation":[{"name":"Student Research Committee, Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4787-1287","authenticated-orcid":false,"given":"Zeinab","family":"Dehghan","sequence":"additional","affiliation":[{"name":"Department of Comparative Biomedical Sciences, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran."},{"name":"Autoimmune Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shayesteh","family":"Mehdinejadiani","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, University of Calgary, Calgary, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra","family":"Khosravizadeh","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, School of medicine, Arak University of Medical Sciences, Arak, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Effat","family":"Noori","sequence":"additional","affiliation":[{"name":"Department of Medical Biotechnology, Faculty of Medicine, Shahed University, Tehran, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tayyebeh","family":"Pilehchi","sequence":"additional","affiliation":[{"name":"Student Research Committee, Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran."},{"name":"Department of microbiology, Immunology and Infectious Diseases, Calgary University, Calgary, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delsuz","family":"Rezaee","sequence":"additional","affiliation":[{"name":"Department of Genetic, School of Allied Medical Sciences, Ilam University of Medical Sciences, Ilam, Iran."},{"name":"Zoonotic Diseases Research Center, Ilam University of Medical Sciences, Ilam, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra","family":"Taheri","sequence":"additional","affiliation":[{"name":"Department of Biology and Biotechnology, University of Pavia, Pavia, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azam","family":"Govahi","sequence":"additional","affiliation":[{"name":"Endometriosis Research Center, Iran University of Medical Sciences, Tehran, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nasim","family":"Goudarzi","sequence":"additional","affiliation":[{"name":"Department of Anatomical Sciences, Cellular and Molecular Research Center, Research Institute for Prevention of Non-communicable Diseases, Qazvin University of Medical Sciences, Qazvin, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kobra","family":"Mehdinejadiani","sequence":"additional","affiliation":[{"name":"Department of microbiology, Immunology and Infectious Diseases, Calgary University, Calgary, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Forough","family":"Shams","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran."},{"name":"Medical Nanotechnology and Tissue Engineering Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,11,20]]},"reference":[{"key":"e_1_3_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.29004"},{"key":"e_1_3_6_3_1","doi-asserted-by":"publisher","DOI":"10.2174\/1574888X14666191119122159"},{"key":"e_1_3_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tice.2020.101351"},{"key":"e_1_3_6_5_1","first-page":"2","article-title":"Infertility: A review on causes, treatment and management","volume":"5","author":"Anwar S","year":"2016","unstructured":"Anwar S, , Anwar A. 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