{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T05:18:51Z","timestamp":1776143931657,"version":"3.50.1"},"reference-count":38,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Allergy\ufffdRhinol (Providence)"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p> Chronic cough in children is a diagnostic challenge. <\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p> To discover the utility of nasal dipsticks and polymerase chain reaction (PCR)-DNA analysis in differentiating bacterial sinusitis from other causes of chronic cough and identifying pathogens from the nasal cavity. <\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p> We recruited 22 patients under 15 years of age with cough lasting longer than 4 weeks (group 1), 7 controls with allergic rhinitis (group 2), and 10 controls without respiratory symptoms (group 3). Based on symptoms, the results of nasal secretion assays, and nasal endoscopy, a diagnosis of clinical bacterial sinusitis was made. We identified potential pathogens by quantitative PCR of nasal secretions. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> Group 1A (cough with clinical bacterial sinusitis n\u2009=\u200910): Eight (80%) patients had bacterial sinusitis associated with dominant potential pathogenic bacteria (PPB): Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis. Group 1B (cough without clinical bacterial sinusitis n\u2009=\u200912): None had dominant PPB. Group 2 (allergic rhinitis n\u2009=\u20097): None had dominant PPB. Group 3 (asymptomatic n\u2009=\u200910): None had dominant PPB. Twenty to 57% of all groups were colonized with Staphylococcus aureus. Fifty to 70% were colonized with Staphylococcus epidermidis, Corynebacterium pseudodiphtheriticum, and Dolosigranulum pigrum. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> In children with chronic cough, clinicians can utilize a simple and inexpensive nasal secretion dipstick assay for rapid diagnosis of sinusitis and identify PPB by DNA-PCR test for specific antibiotic treatment. <\/jats:p><\/jats:sec>","DOI":"10.1177\/2152656718821281","type":"journal-article","created":{"date-parts":[[2019,1,8]],"date-time":"2019-01-08T22:40:54Z","timestamp":1546987254000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Use of Dipstick Assay and Rapid PCR-DNA Analysis of Nasal Secretions for Diagnosis of Bacterial Sinusitis in Children With Chronic Cough"],"prefix":"10.1177","volume":"10","author":[{"given":"Charles","family":"Song","sequence":"first","affiliation":[{"name":"Division of Allergy and Immunology, Department of Pediatrics, Harbor UCLA Medical Center, Torrance, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeena","family":"Chorath","sequence":"additional","affiliation":[{"name":"Division of Allergy and Immunology, Department of Pediatrics, Harbor UCLA Medical Center, Torrance, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youngju","family":"Pak","sequence":"additional","affiliation":[{"name":"Division of Allergy and Immunology, Department of Pediatrics, Harbor UCLA Medical Center, Torrance, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nasser","family":"Redjal","sequence":"additional","affiliation":[{"name":"Division of Allergy and Immunology, Department of Pediatrics, Harbor UCLA Medical Center, Torrance, California"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,1,7]]},"reference":[{"key":"bibr1-2152656718821281","doi-asserted-by":"publisher","DOI":"10.1378\/chest.15-1403"},{"key":"bibr2-2152656718821281","doi-asserted-by":"publisher","DOI":"10.1378\/chest.11-2725"},{"key":"bibr3-2152656718821281","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2017.06.006"},{"key":"bibr4-2152656718821281","doi-asserted-by":"publisher","DOI":"10.1378\/chest.08-0885"},{"key":"bibr5-2152656718821281","unstructured":"National Asthma Education and Prevention Program. 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