{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T07:55:06Z","timestamp":1768463706022,"version":"3.49.0"},"reference-count":18,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Japanese Society of Laboratory Medicine Fund for Promotion of Scientific Research"},{"DOI":"10.13039\/501100001691","name":"Grants-in-Aid for Scientific Research","doi-asserted-by":"crossref","award":["16K08926"],"award-info":[{"award-number":["16K08926"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001691","name":"Grants-in-Aid for Scientific Research","doi-asserted-by":"crossref","award":["19K07949"],"award-info":[{"award-number":["19K07949"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Allergy\ufffdRhinol (Providence)"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p> Eosinophilic cholecystitis (EC) is a rare condition that presents in a manner comparable to acute cholecystitis. The diagnosis is based on classical symptoms of cholecystitis with excessive eosinophilic infiltration within the gallbladder. EC has been reported alone or in combination with manifestations, such as eosinophilic gastrointestinal tract inflammation. However, association with airway inflammation in patients with EC is rare. Case Presentation: We report the case of a 65-year-old man who had refractory eosinophilic chronic rhinosinusitis with bronchial asthma. A second endoscopic sinus surgery (ESS) was performed as treatment for recurrent nasal polyps. EC occurred while inhaled corticosteroids were reduced after ESS. Pathologic examination of the excised gallbladder demonstrated submucosal infiltration with a number of eosinophils. Furthermore, immunohistostaining revealed many galectin-10-positive cells in both the gallbladder mucosa and the paranasal sinus mucosa. Galectin-10 is a major constituent of human eosinophils, also known as the Charcot\u2013Leyden crystal protein, which has been linked with eosinophilic inflammation. Interestingly, nasal polyps were reduced without any additional treatments 1 month after the cholecystectomy. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p> We experienced a rare case wherein EC onset occurred in a patient with refractory eosinophilic airway inflammation during inhaled corticosteroid tapering. Galectin-10 might help diagnose rare cases of eosinophilic inflammation in multiple organs. <\/jats:p><\/jats:sec>","DOI":"10.1177\/2152656719869607","type":"journal-article","created":{"date-parts":[[2019,8,19]],"date-time":"2019-08-19T09:25:29Z","timestamp":1566206729000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Eosinophilic Cholecystitis Occurred in a Patient With Refractory Eosinophilic Airway Inflammation: A Case Report"],"prefix":"10.1177","volume":"10","author":[{"given":"Toshiaki","family":"Kuwahara","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, Kansai Medical University, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3755-3074","authenticated-orcid":false,"given":"Yoshiki","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Kansai Medical University, Osaka, Japan"},{"name":"Allergy Center, Kansai Medical University Hospital, Hirakata, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasutaka","family":"Yun","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Kansai Medical University, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Kanda","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Kansai Medical University, Osaka, Japan"},{"name":"Allergy Center, Kansai Medical University Hospital, Hirakata, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikiya","family":"Asako","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Kansai Medical University, Osaka, Japan"},{"name":"Allergy Center, Kansai Medical University Hospital, Hirakata, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeharu","family":"Ueki","sequence":"additional","affiliation":[{"name":"Department of General Medical Practice and Laboratory Diagnostic Medicine, Akita University Graduate School of Medicine, Akita, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Iwai","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Kansai Medical University, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,8,19]]},"reference":[{"issue":"2","key":"bibr1-2152656719869607","first-page":"182","volume":"37","author":"Shakov R","year":"2007","journal-title":"Ann Clin Lab Sci"},{"key":"bibr2-2152656719869607","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(19)33192-0"},{"issue":"7","key":"bibr3-2152656719869607","first-page":"572","volume":"80","author":"Butler TW","year":"1985","journal-title":"Am J Gastroenterol"},{"key":"bibr4-2152656719869607","doi-asserted-by":"publisher","DOI":"10.1111\/all.12644"},{"key":"bibr5-2152656719869607","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02192"},{"key":"bibr6-2152656719869607","doi-asserted-by":"publisher","DOI":"10.5414\/CP202100"},{"key":"bibr7-2152656719869607","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.09.005"},{"key":"bibr8-2152656719869607","doi-asserted-by":"publisher","DOI":"10.1111\/cea.13382"},{"key":"bibr9-2152656719869607","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M200221200"},{"key":"bibr10-2152656719869607","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-04-842260"},{"key":"bibr11-2152656719869607","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaw4295"},{"key":"bibr12-2152656719869607","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-019-0868-0"},{"key":"bibr13-2152656719869607","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2009.02141.x"},{"key":"bibr14-2152656719869607","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0042549"},{"issue":"3","key":"bibr15-2152656719869607","first-page":"77","volume":"80","author":"Fujibayashi M","year":"2010","journal-title":"J Tokyo Wom Med Univ"},{"issue":"1","key":"bibr16-2152656719869607","first-page":"45","volume":"107","author":"del-Moral-Martinez M","year":"2015","journal-title":"Rev Esp Enferm Dig"},{"key":"bibr17-2152656719869607","doi-asserted-by":"publisher","DOI":"10.1100\/2012\/474020"},{"key":"bibr18-2152656719869607","doi-asserted-by":"publisher","DOI":"10.2217\/bmm-2018-0280"}],"container-title":["Allergy &amp; 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