{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T12:44:31Z","timestamp":1779885871671,"version":"3.53.1"},"reference-count":17,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["KL2TR002490"],"award-info":[{"award-number":["KL2TR002490"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Allergy\ufffdRhinol (Providence)"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p> Extramedullary hematopoiesis (EMH) occurs in patients with hematologic disorders, but rarely within the paranasal sinuses. We report a case of EMH in a 17-year-old male with sickle cell disease (SCD) who presented with occipital pain and sinusitis. A computed tomography (CT) scan demonstrated heterogeneous opacification of the right maxillary sinus concerning for allergic fungal sinusitis or a fungal ball with bony erosion. He was taken to the operating room for endoscopic biopsy and a limited endoscopic sinus surgery. Grossly, his maxillary sinus was filled with spiculated osseous tissue. Final pathology demonstrated active hematopoietic bone marrow filling the sinus. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p> We present a case report and literature review of sinonasal EMH. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> We identified 14 articles with 15 patients. EMH was typically associated with SCD or beta thalassemia. The average age of presentation was 30. There was a male sex predilection with a ratio of 11:15. The most common presenting symptom was a headache and nasal obstruction (33% for both). The most common finding on CT was a soft tissue expansile mass (73%). The most commonly affected location was the maxillary sinus (60%). <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p> This case report serves as a reminder to consider EMH as an uncommon cause of sinus opacification, particularly in patients with SCD or beta thalassemia. The expansion of hematopoietic tissue may be identified as a sinus mass on CT. By recognizing the potential manifestations of chronic anemia, an accurate and timely diagnosis can be made. <\/jats:p><\/jats:sec>","DOI":"10.1177\/2152656720918874","type":"journal-article","created":{"date-parts":[[2020,4,22]],"date-time":"2020-04-22T04:18:48Z","timestamp":1587529128000},"page":"215265672091887","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Extramedullary Hematopoiesis in the Sinonasal Cavity: A Case Report and Review of the Literature"],"prefix":"10.1177","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6199-4940","authenticated-orcid":false,"given":"Carly A.","family":"Clark","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, University of North Carolina, Chapel Hill, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cameron P.","family":"Worden","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, University of North Carolina, Chapel Hill, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian D.","family":"Thorp","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, University of North Carolina, Chapel Hill, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Charles S.","family":"Ebert","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, University of North Carolina, Chapel Hill, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam M.","family":"Zanation","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, University of North Carolina, Chapel Hill, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brent A.","family":"Senior","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, University of North Carolina, Chapel Hill, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"M. Johnson","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wade G.","family":"McClain","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, University of North Carolina, Chapel Hill, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1670-8401","authenticated-orcid":false,"given":"Adam J.","family":"Kimple","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, University of North Carolina, Chapel Hill, North Carolina"},{"name":"Marsico Lung Institute, University of North Carolina, Chapel Hill, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,4,21]]},"reference":[{"key":"bibr1-2152656720918874","doi-asserted-by":"publisher","DOI":"10.1148\/rg.304095171"},{"key":"bibr2-2152656720918874","doi-asserted-by":"publisher","DOI":"10.1016\/j.pedex.2008.05.007"},{"key":"bibr3-2152656720918874","doi-asserted-by":"publisher","DOI":"10.1111\/j.1754-9485.2012.02397.x"},{"key":"bibr4-2152656720918874","doi-asserted-by":"publisher","DOI":"10.1097\/00004728-198408000-00042"},{"issue":"1","key":"bibr5-2152656720918874","first-page":"76","volume":"128","author":"Kearney PR","year":"2002","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"bibr6-2152656720918874","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2004.07.007"},{"key":"bibr7-2152656720918874","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2014.03.028"},{"key":"bibr8-2152656720918874","doi-asserted-by":"publisher","DOI":"10.1097\/00004728-198402000-00048"},{"key":"bibr9-2152656720918874","doi-asserted-by":"publisher","DOI":"10.1007\/BF03545633"},{"key":"bibr10-2152656720918874","doi-asserted-by":"publisher","DOI":"10.1007\/s002340050037"},{"key":"bibr11-2152656720918874","doi-asserted-by":"publisher","DOI":"10.1177\/014556130108001010"},{"issue":"4","key":"bibr12-2152656720918874","first-page":"376","volume":"105","author":"Rizzo L","year":"2003","journal-title":"La Radiol Med"},{"key":"bibr13-2152656720918874","doi-asserted-by":"publisher","DOI":"10.1177\/014556130408300414"},{"issue":"4","key":"bibr14-2152656720918874","first-page":"809","volume":"90","author":"Ittipunkul N","year":"2007","journal-title":"J Med Assoc Thailand"},{"key":"bibr15-2152656720918874","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2009.03.008"},{"key":"bibr16-2152656720918874","doi-asserted-by":"publisher","DOI":"10.1177\/0194599811415823a407"},{"key":"bibr17-2152656720918874","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2012.11.004"}],"container-title":["Allergy &amp; Rhinology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2152656720918874","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2152656720918874","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2152656720918874","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T18:10:23Z","timestamp":1741025423000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.sagepub.com\/doi\/10.1177\/2152656720918874"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":17,"alternative-id":["10.1177\/2152656720918874"],"URL":"https:\/\/doi.org\/10.1177\/2152656720918874","relation":{},"ISSN":["2152-6567","2152-6567"],"issn-type":[{"value":"2152-6567","type":"print"},{"value":"2152-6567","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1]]}}}