{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:09:57Z","timestamp":1777374597993,"version":"3.51.4"},"reference-count":17,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Allergy\ufffdRhinol (Providence)"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Various graft materials that are classified as autografts, xenografts, and allografts based on their origin have been used to endoscopically repair skull base defects. Tutoplast\u00ae (Tutogen Medical GmbH), an allogeneic natural collagen matrix, is processed through chemical sterilization that preserves tissue biocompatibility and structural integrity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To study the safety and efficacy of Tutoplast Fascia Lata and Tutoplast Temporalis Fascia\u00ae as primary graft materials in the endoscopic reconstruction of skull base defects of different sizes and etiologies and to compare the outcomes with those of other traditional graft materials based on our experience.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This is a multi-center retrospective chart review of patients who underwent cerebrospinal fluid leak (CSF) endoscopic reconstruction with Tutoplast Fascia Lata or Tutoplast Temporalis Fascia as either a stand-alone reconstruction material or a part of a multilayer reconstruction depending on the defect at Prince Sultan Military Medical City and King Faisal Specialist Hospital and Research Center in Riyadh, Saudi Arabia, between 2017 and 2020. Our inclusion criteria were CSF leak repair with Tutoplast and a transnasal endoscopic approach. We reviewed demographic data, intraoperative and postoperative complications, repair materials, repair failure, defect size and location.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Tutoplast\u00ae was used as the primary graft material in 33 cases. Our main outcome was repair success with lack of post operative CSF leak, observed in 30 cases (90.9%). There was no significant association between postoperative CSF leaks and factors including different defect sizes, defect sites, demographic data, hospitalization duration, or postoperative radiation in oncological cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Tutoplast alone or in combination with other materials can be used safely and effectively for skull base defects repair.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/21526567211009200","type":"journal-article","created":{"date-parts":[[2021,4,9]],"date-time":"2021-04-09T04:33:55Z","timestamp":1617942835000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Endoscopic Reconstruction of Skull Base Defects Using Tutoplast"],"prefix":"10.1177","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9780-2485","authenticated-orcid":false,"given":"Ghassan","family":"Alokby","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery, King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia"},{"name":"Department of Surgery, College of Medicine, Al Faisal University, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kholoud Mohammed","family":"AlAmari","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery, King Saud Medical City, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jamal Mohammed S.","family":"Abdullah","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Prince Sultan Military Medical City, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed","family":"Tayed Hazazi","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery, King Saud Medical City, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fawaz","family":"Makki","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery, King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia"},{"name":"Department of Surgery, College of Medicine, Al Faisal University, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,4,9]]},"reference":[{"key":"bibr1-21526567211009200","doi-asserted-by":"crossref","unstructured":"Snyderman CH, Carrau RL, Prevedello DM, Gardner P, Kassam AB. Technologic innovations in neuroendoscopic surgery.\n                      Otolaryngol Clin North Am\n                      . 2009 Oct;42(5):883\u201390, x. doi: 10.1016\/j.otc.2009.08.019. PMID: 19909866.","DOI":"10.1016\/j.otc.2009.08.019"},{"key":"bibr2-21526567211009200","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.30831"},{"issue":"4","key":"bibr3-21526567211009200","first-page":"191","volume":"29","author":"Presutti L","year":"2009","journal-title":"Acta Otorhinolaryngol Ital"},{"key":"bibr4-21526567211009200","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215117001499"},{"key":"bibr5-21526567211009200","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21627"},{"key":"bibr6-21526567211009200","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-959337"},{"key":"bibr7-21526567211009200","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2014.07.018"},{"key":"bibr8-21526567211009200","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2016.12.005"},{"key":"bibr9-21526567211009200","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2016.30.4356"},{"key":"bibr10-21526567211009200","doi-asserted-by":"publisher","DOI":"10.2500\/ajr.2007.21.3080"},{"key":"bibr11-21526567211009200","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1253573"},{"key":"bibr12-21526567211009200","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21783"},{"key":"bibr13-21526567211009200","doi-asserted-by":"publisher","DOI":"10.1055\/s-0033-1338263"},{"key":"bibr14-21526567211009200","doi-asserted-by":"publisher","DOI":"10.3171\/JNS-07\/10\/0713"},{"key":"bibr15-21526567211009200","doi-asserted-by":"publisher","DOI":"10.3171\/FOC.2008.25.12.E8"},{"key":"bibr16-21526567211009200","doi-asserted-by":"publisher","DOI":"10.1007\/s10143-012-0403-4"},{"key":"bibr17-21526567211009200","unstructured":"Consortium C, Khan DZ, Marcus HJ, et\u00a0al. CSF rhinorrhoea after endonasal intervention to the skull base (CRANIAL): part 1: multicentre pilot study [published online ahead of print January 15, 2021].\n                      World Neurosurg\n                      . doi:10.1016\/j.wneu"}],"container-title":["Allergy &amp; Rhinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/21526567211009200","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/21526567211009200","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/21526567211009200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T08:59:17Z","timestamp":1777366757000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/21526567211009200"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":17,"alternative-id":["10.1177\/21526567211009200"],"URL":"https:\/\/doi.org\/10.1177\/21526567211009200","relation":{},"ISSN":["2152-6575","2152-6567"],"issn-type":[{"value":"2152-6575","type":"print"},{"value":"2152-6567","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1]]},"article-number":"21526567211009200"}}