{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:09:57Z","timestamp":1777374597973,"version":"3.51.4"},"reference-count":6,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Allergy\ufffdRhinol (Providence)"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>Chronic spontaneous urticaria (CSU, chronic idiopathic urticaria) is a clinical diagnosis characterized by recurrent urticaria of unknown origin, with or without angioedema, that occurs for six weeks or longer. Management of CSU includes a second-generation H1 antihistamine and\/or elimination of exacerbating factors. If initial treatment is unsuccessful, trials of first generation H1 antihistamine, H2 blocking antihistamine, leukotriene-receptor antagonist, anti-inflammatory or immunosuppressive agents may be administered. Exacerbating factors include stress, environmental conditions, medications, physical stimuli, and infections. We report the first two cases of a COVID-19 vaccine triggered relapse of CSU that was previously well controlled on therapy.<\/jats:p>","DOI":"10.1177\/21526567211026271","type":"journal-article","created":{"date-parts":[[2021,6,25]],"date-time":"2021-06-25T00:43:00Z","timestamp":1624581780000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":19,"title":["Two Cases of Well Controlled Chronic Spontaneous Urticaria Triggered by the Moderna COVID-19 Vaccine"],"prefix":"10.1177","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8243-1581","authenticated-orcid":false,"given":"Cylie","family":"Alflen","sequence":"first","affiliation":[{"name":"Lake Erie College of Osteopathic Medicine, Erie, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katheryn","family":"Birch","sequence":"additional","affiliation":[{"name":"Allergy\/Immunology Associates Inc., Mayfield Heights, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan","family":"Shilian","sequence":"additional","affiliation":[{"name":"Allergy\/Immunology Associates Inc., Mayfield Heights, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shan Shan","family":"Wu","sequence":"additional","affiliation":[{"name":"Allergy\/Immunology Associates Inc., Mayfield Heights, Ohio"},{"name":"Cleveland Medical Center, University Hospitals, Cleveland, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr","given":"Robert","family":"Hostoffer","sequence":"additional","affiliation":[{"name":"Allergy\/Immunology Associates Inc., Mayfield Heights, Ohio"},{"name":"Cleveland Medical Center, University Hospitals, Cleveland, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,6,24]]},"reference":[{"key":"bibr1-21526567211026271","doi-asserted-by":"publisher","DOI":"10.2174\/1872213X13666190328164931"},{"key":"bibr2-21526567211026271","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-017-8628-1"},{"issue":"3","key":"bibr3-21526567211026271","first-page":"1","volume":"23","author":"Westby EP","year":"2018","journal-title":"Skin Ther Lett"},{"key":"bibr4-21526567211026271","author":"Johnston MS","journal-title":"JAMA Dermatol"},{"key":"bibr5-21526567211026271","author":"McMahon DE","journal-title":"J Am Acad Dermatol"},{"key":"bibr6-21526567211026271","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2035389"}],"container-title":["Allergy &amp; Rhinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/21526567211026271","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/21526567211026271","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/21526567211026271","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T08:59:18Z","timestamp":1777366758000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/21526567211026271"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":6,"alternative-id":["10.1177\/21526567211026271"],"URL":"https:\/\/doi.org\/10.1177\/21526567211026271","relation":{},"ISSN":["2152-6575","2152-6567"],"issn-type":[{"value":"2152-6575","type":"print"},{"value":"2152-6567","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1]]},"article-number":"21526567211026271"}}