{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:41:19Z","timestamp":1791301279681,"version":"4.1.0"},"reference-count":25,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"The study was sponsored by Aerin Medical."}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Allergy\ufffdRhinol (Providence)"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Temperature-controlled radiofrequency neurolysis of the posterior nasal nerve has been shown to reduce the symptom burden of patients with chronic rhinitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate the long-term safety and effectiveness of temperature-controlled radiofrequency neurolysis of the posterior nasal nerve for the treatment of chronic rhinitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A prospective extension of a 12-month single-arm study, where reflective total nasal symptom score (rTNSS) and the responses to a study-specific quality of life questionnaire and patient satisfaction survey were collected at 24 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Forty-seven patients completed initial 12-month follow-up after treatment with the study device, of which 34 patients were reconsented and completed 24-month follow-up. The mean rTNSS of the long-term follow-up patients improved from 8.4 (95% confidence interval (CI), 7.7 to 9.0) at baseline to 2.9 (95% CI, 2.1 to 3.6), P\u2009&lt;\u2009.001 at 24 months, a 65.5% improvement. On a 6-point scale (0-5), postnasal drip improved from a mean of 4.1 (95% CI, 3.6 to 4.6) to 2.1 (95% CI, 1.7 to 2.5) and chronic cough improved from 3.2 (95% CI, 2.7 to 3.6) to 0.9 (95% CI, 0.5 to 1.3) from baseline through 24 months; P\u2009&lt;\u2009.001 for both measures. The proportion of patients achieving a minimal clinically important difference of 30% improvement from baseline at 24 months was 88.2% (95% CI, 73.4%-95.3%). At 24 months, 24% of patients were taking overall fewer and 15% taking overall more rhinitis medication classes than at baseline. Patients reported a higher quality of life in terms of sleep, well-being, and lower oral medication\/nasal spray use at 24 months. There were no serious adverse events considered related to the procedure in the 12-24-month period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Temperature-controlled radiofrequency neurolysis results in a significant and durable reduction in the symptom burden of chronic rhinitis and patients reported improved quality of life through 24 months postprocedure.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/21526575221096045","type":"journal-article","created":{"date-parts":[[2022,5,30]],"date-time":"2022-05-30T02:54:57Z","timestamp":1653879297000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":31,"title":["Long-term Outcomes Following Temperature-Controlled Radiofrequency Neurolysis for the Treatment of Chronic Rhinitis"],"prefix":"10.1177","volume":"13","author":[{"given":"Dale","family":"Ehmer","sequence":"first","affiliation":[{"name":"Ear, Nose, and Throat Associates of Texas, McKinney, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chad M.","family":"McDuffie","sequence":"additional","affiliation":[{"name":"Ear, Nose, and Throat Associates of Texas, McKinney, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Bradley","family":"McIntyre","sequence":"additional","affiliation":[{"name":"Fort Worth ENT Group, Fort Worth, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan M.","family":"Davis","sequence":"additional","affiliation":[{"name":"Colorado ENT and Allergy, Colorado Springs, Colorado, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neelesh H.","family":"Mehendale","sequence":"additional","affiliation":[{"name":"Ear, Nose, and Throat Associates of Texas, McKinney, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John H.","family":"Willis","sequence":"additional","affiliation":[{"name":"Piedmont Ear, Nose, and Throat Associates, Winston-Salem, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy P.","family":"Watkins","sequence":"additional","affiliation":[{"name":"Fort Worth ENT Group, Fort Worth, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6694-4598","authenticated-orcid":false,"given":"V. Vasu","family":"Kakarlapudi","sequence":"additional","affiliation":[{"name":"Advanced ENT and Allergy, New Albany, Indiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,5,29]]},"reference":[{"key":"bibr1-21526575221096045","doi-asserted-by":"publisher","DOI":"10.1016\/j.otot.2007.05.010"},{"key":"bibr2-21526575221096045","first-page":"1907862","author":"Takahara D","year":"2017","journal-title":"Int J Otolaryngol"},{"key":"bibr3-21526575221096045","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-009-0914-y"},{"key":"bibr4-21526575221096045","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200303000-00022"},{"key":"bibr5-21526575221096045","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200405000-00016"},{"key":"bibr6-21526575221096045","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-010-0093-3"},{"key":"bibr7-21526575221096045","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-016-0636-3"},{"issue":"105","key":"bibr8-21526575221096045","first-page":"203","volume":"31","author":"Zand V","year":"2019","journal-title":"Iran J Otorhinolaryngol"},{"key":"bibr9-21526575221096045","doi-asserted-by":"publisher","DOI":"10.1177\/2473974X211041124"},{"key":"bibr10-21526575221096045","doi-asserted-by":"publisher","DOI":"10.1177\/19458924211033400"},{"key":"bibr11-21526575221096045","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2009.03381.x"},{"key":"bibr12-21526575221096045","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2016.02.006"},{"key":"bibr13-21526575221096045","doi-asserted-by":"publisher","DOI":"10.1017\/S0266462316000593"},{"key":"bibr14-21526575221096045","unstructured":"Glacy J, Putnam K, Godfrey S, et al. 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