{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:25:03Z","timestamp":1787171103217,"version":"build-2736575974"},"reference-count":21,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Hypothermia and Temperature Management"],"abstract":"<jats:p>Intravascular temperature management (IVTM) is widely used for temperature control after cardiac arrest, but its association with IVTM-related venous thromboembolism (VTE) remains clinically important. D-dimer is commonly used for VTE evaluation, although interpretation is challenging after cardiac arrest because coagulation and fibrinolytic abnormalities can elevate D-dimer values. We conducted a single-center retrospective cohort study of out-of-hospital cardiac arrest patients treated with IVTM between August 2021 and August 2024. D-dimer levels were measured daily for 7 days and reported in \u00b5g\/mL D-dimer units. IVTM-related VTE diagnosed within 10 days after admission was identified from medical records. Delta D-dimer was defined as the increase from each baseline value on Days 1, 2, or 3 to the peak value within 7 days. Among 51 patients, 8 (15.7%) developed IVTM-related VTE; the median time to diagnosis was 5.5 days. Peak D-dimer was higher in patients with IVTM-related VTE than in those without IVTM-related VTE (56.0 vs. 17.4 \u00b5g\/mL DDU). Delta D-dimer was associated with IVTM-related VTE in adjusted logistic regression models, with adjusted odds ratios ranging from 1.04 to 1.10 per 1 \u00b5g\/mL increase. In post-cardiac arrest patients undergoing IVTM, increases in D-dimer from early-phase values to peak were associated with IVTM-related VTE. Serial D-dimer assessment may help identify patients who warrant targeted imaging when IVTM-related VTE is clinically suspected.<\/jats:p>","DOI":"10.1177\/21537658261480396","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T06:12:07Z","timestamp":1787033527000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Association between D-Dimer Trends and Intravascular Temperature Management-Related Venous Thromboembolism after Cardiac Arrest: A Single-Center Observational Study"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1790-2740","authenticated-orcid":false,"given":"Ryosuke","family":"Nobe","sequence":"first","affiliation":[{"name":"Department of Acute Medicine and Critical Care Medical Centre, National Hospital Organization Osaka National Hospital, Osaka, 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