{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T13:51:34Z","timestamp":1791381094934,"version":"4.3.3"},"reference-count":21,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T00:00:00Z","timestamp":1762732800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Adolescent and Young Adult Oncology"],"published-print":{"date-parts":[[2026,6,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Aim:<\/jats:title>\n                    <jats:p>Adolescent and young adult (AYA) patients who require pancreatectomy are rare. There are few reports concerning the characteristics of AYA patients undergoing pancreatectomy for malignant tumors. This study aimed to clarify the characteristics and outcomes of AYA patients who had undergone pancreatectomy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>AYA patients (age 15\u201335 years) who underwent pancreatectomy at our institution between 1995 and 2018 were included in this study. The diagnosis, operative procedure, complications, mortality, and survival were retrospectively analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Forty-seven patients underwent pancreatectomy (median age 29 years; range, 16\u201335 years). The diagnoses were solid-pseudopapillary neoplasm (SPN;\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 21 [44.6%]), neuroendocrine neoplasm (NEN;\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 12 [25.5%]), adenocarcinoma (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 5 [10.6%]), and others (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 9 [19.1%]). The surgical procedures included pancreatoduodenectomy (PD;\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 17 [36.1%]), distal pancreatectomy (DP;\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 18 [38.2%]), middle pancreatectomy (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 8 [17.0%]), and tumor enucleation (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 4 [8.5%]). The most common postoperative complication was pancreatic fistula (POPF) (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 29 [61.7%]). Hemorrhage was noted in one case, but the surgical mortality rate was 0%. Long-term complications included four cases of pancreatitis, three cases of diabetes, two cases of bowel obstruction, and one case of cholangitis. The 5-year recurrence-free-survival (RFS) and overall-survival (OS) rates in patients with SPN\/NEN\/others were 91.8% and 97.5%, respectively. In contrast, the 5-year RFS and OS rates in patients with adenocarcinoma were 53.3% and 80.0%, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Most AYA patients who underwent pancreatectomy had low-grade malignancies and showed a favorable survival. Although POPF and pancreatitis frequently occur, radical surgery\u2014even major pancreatectomy such as PD and DP\u2014is feasible and effective in AYA patients with malignant tumors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/21565333251394590","type":"journal-article","created":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T09:47:22Z","timestamp":1762768042000},"page":"220-225","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Characteristics of Adolescent and Young Adult Patients Undergoing Pancreatectomy for Malignant Tumors: A 20-Year Single Institution Experience"],"prefix":"10.1177","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0010-4902","authenticated-orcid":false,"given":"Naonori","family":"Kawakubo","sequence":"first","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Surgery, National Cancer Center Hospital, Tokyo, Japan."},{"name":"Department of Pediatric Surgical Oncology, National Cancer Center Hospital, Chuo, Japan."},{"name":"Department of Pediatric Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minoru","family":"Esaki","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Surgery, National Cancer Center Hospital, Tokyo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Nara","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Surgery, National Cancer Center Hospital, Tokyo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akinori","family":"Miyata","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Surgery, National Cancer Center Hospital, Tokyo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Mizui","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Surgery, National Cancer Center Hospital, Tokyo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryosuke","family":"Umino","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Surgery, National Cancer Center Hospital, Tokyo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junkichi","family":"Takemoto","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgical Oncology, National Cancer Center Hospital, Chuo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoro","family":"Hishiki","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgical Oncology, National Cancer Center Hospital, Chuo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiro","family":"Yoneda","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgical Oncology, National Cancer Center Hospital, Chuo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,11,10]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2016.04.049"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2006.08.024"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.22385"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2011.11.046"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2012.09.005"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2017.06.024"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000006438"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2005.01.044"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0b013e318232a6e2"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2015.08.010"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2019.08.051"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2016.11.014"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2007.02.001"},{"key":"e_1_3_4_15_2","volume-title":"General Rules for the Study of Pancreatic Cancer","author":"Japan Pancreas Society","year":"2016","unstructured":"Japan Pancreas Society. General Rules for the Study of Pancreatic Cancer. 7th ed. Kanehara & Co., Ltd: Tokyo; 2016.","edition":"7"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.25986"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.7150\/jca.24491"},{"key":"e_1_3_4_18_2","unstructured":"Neuroendocrine tumors. Version2.2414.NCCN Clinical Practice Guidelines in Oncology. Available from: http:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/neuroendocrine.pdf [Last accessed: January11 2019]."},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-020-04565-y"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000002620"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-017-3356-7"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hpb.2018.04.003"}],"container-title":["Journal of Adolescent and Young Adult Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/21565333251394590","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/21565333251394590","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/21565333251394590","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T12:56:45Z","timestamp":1791377805000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/21565333251394590"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,10]]},"references-count":21,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,6,1]]}},"alternative-id":["10.1177\/21565333251394590"],"URL":"https:\/\/doi.org\/10.1177\/21565333251394590","relation":{},"ISSN":["2156-5333","2156-535X"],"issn-type":[{"value":"2156-5333","type":"print"},{"value":"2156-535X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,10]]}}}