{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T05:36:14Z","timestamp":1793165774143,"version":"4.5.0"},"reference-count":66,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T00:00:00Z","timestamp":1773964800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"National Cancer Institute","award":["R21CA263727-01A1"],"award-info":[{"award-number":["R21CA263727-01A1"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Adolescent and Young Adult Oncology"],"published-print":{"date-parts":[[2026,12,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>High symptom burden and poor prognosis faced by adolescents and young adults (AYAs; aged 15\u201329) with advanced or recurrent cancer significantly impact their sense of identity and purpose as they work to achieve developmentally significant goals. The combination of high symptom burden and goal interference may exacerbate suffering, yet palliative care interventions have not addressed the co-occurring symptom management and existential concerns of this population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Guided by the NIH Stage Model, we systematically developed a psychosocial symptom management intervention to address the needs of AYAs with advanced or recurrent cancer. Quantitative and qualitative data were obtained from AYAs (\n                      <jats:italic toggle=\"yes\">N<\/jats:italic>\n                      = 20) and caregivers (\n                      <jats:italic toggle=\"yes\">N<\/jats:italic>\n                      = 13) who completed semi-structured interviews and self-report measures to assist with intervention development of refinement. Rapid qualitative analysis was used.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Intervention development interviews confirmed high symptom burden and the need to develop a psychosocial symptom management intervention targeting this population. A four-session intervention (\u201cSMILE:\n                      <jats:underline>S<\/jats:underline>\n                      ymptom\n                      <jats:underline>M<\/jats:underline>\n                      anagement for\n                      <jats:underline>I<\/jats:underline>\n                      mproved Physica\n                      <jats:underline>L<\/jats:underline>\n                      and\n                      <jats:underline>E<\/jats:underline>\n                      motional Wellbeing\u201d) was developed integrating behavioral symptom coping strategies with strategies from Meaning-Centered Psychotherapy and Acceptance and Commitment Therapy to (a) reduce symptom burden and interference and (b) promote engagement in values-driven, meaningful action in the face of life-limiting illness. Refinement sessions assisted with further clarifying concepts, tailoring the intervention to the population, and honing protocols.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>SMILE is a novel integration of three evidence-based approaches to provide AYAs skills to address symptoms that interfere with valued and meaningful action. The feasibility and acceptability of SMILE will next be examined in a pilot randomized controlled trial.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/21565333261425871","type":"journal-article","created":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T08:11:21Z","timestamp":1773994281000},"page":"424-440","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Development of a Novel Psychosocial Intervention to Improve Symptom Management for Adolescents and Young Adults with Advanced or Recurrent Cancer"],"prefix":"10.1177","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2391-1128","authenticated-orcid":false,"given":"Caroline S.","family":"Dorfman","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, North Carolina, USA."},{"name":"Supportive Care and Survivorship Center, Duke Cancer Institute, Durham, North Carolina, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara J.","family":"Somers","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, North Carolina, USA."},{"name":"Supportive Care and Survivorship Center, Duke Cancer Institute, Durham, North Carolina, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole A.","family":"Arrato","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, North Carolina, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph G.","family":"Winger","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, North Carolina, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brianna","family":"Herold","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, North Carolina, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Plumb Vilardaga","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, North Carolina, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie A.","family":"Chou","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, North Carolina, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison","family":"Diachina","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, North Carolina, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheyenne M.","family":"Corbett","sequence":"additional","affiliation":[{"name":"Supportive Care and Survivorship Center, Duke Cancer Institute, Durham, North Carolina, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Wagner","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology, Department of Pediatrics, Duke University School of Medicine, Durham, North Carolina, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Maslow","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, North Carolina, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William S.","family":"Breitbart","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, New York, New York, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,3,20]]},"reference":[{"key":"e_1_3_3_2_2","volume-title":"Cancer Epidemiology in Older Adolescents and Young Adults 15 to 29 Years of Age, Including SEER Incidence and Survival: 1975-2000","author":"Bleyer A","year":"2006","unstructured":"Bleyer A, , O\u2019Leary M, , Bar R. Cancer Epidemiology in Older Adolescents and Young Adults 15 to 29 Years of Age, Including SEER Incidence and Survival: 1975-2000. NIH: Bethesda, MD; 2006."},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21637"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.27397"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-004-0738-1"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000000135"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.3816\/CBC.2002.n.013"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-6-194"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/jncimonographs\/lgu019"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/COC.0000000000000304"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s005200050281"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1089\/jayao.2014.0015"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1200\/jco.23.00709"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1177\/107327481502200413"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.soncn.2015.05.002"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2011.09.008"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1080\/07347332.2013.835018"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.15761\/.1000101"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.soncn.2015.05.006"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2011.39.5467"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1089\/jayao.2018.0048"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29834"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/pon.3785"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1177\/1043454208321117"},{"issue":"14","key":"e_1_3_3_25_2","first-page":"SP476","article-title":"The challenge of palliative care for adolescents and young adults","volume":"21","author":"Anderson CP","year":"2015","unstructured":"Anderson CP. The challenge of palliative care for adolescents and young adults. The Am J Managed Care Evidence Based Oncol, 2015; 21(14):SP476\u2013SP477.","journal-title":"The Am J Managed Care Evidence Based Oncol"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2009.22.4543"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2014-0265"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.26044"},{"key":"e_1_3_3_29_2","first-page":"41","article-title":"Palliative care for adolescents and young adults with cancer","volume":"3","author":"Rosenberg AR","year":"2013","unstructured":"Rosenberg AR, , Wolfe J. Palliative care for adolescents and young adults with cancer. Clin Oncol Adolesc Young Adults, 2013; 3:41\u201348.","journal-title":"Clin Oncol Adolesc Young Adults"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1177\/1043454220919713"},{"key":"e_1_3_3_31_2","unstructured":"PSYPACT. TPIC. PSYPACT Annual Report 2022. 2022."},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1191\/0269216306pm1110oa"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1188\/05.ONF.1190-1198"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.57.2198"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.77.1097"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1177\/2167702613497932"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1002\/pon.1556"},{"key":"e_1_3_3_38_2","first-page":"475","volume-title":"Psycho-Oncology","author":"Lichtenthal WG","year":"2015","unstructured":"Lichtenthal WG, , Applebaum A, , Breitbart WS. Meaning-Centered Psychotherapy. In: Psycho-Oncology. (Holland JC, , Breitbart WS, , Butow PN, et al. eds.) Oxford University Press: New York; 2015; pp. 475\u2013479."},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brat.2005.06.006"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1177\/0033294117726061"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.994934"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cct.2024.107545"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2015.04.013"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1002\/pon.5141"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.2196\/mhealth.8565"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2019.09.005"},{"key":"e_1_3_3_47_2","article-title":"A feasible and acceptable multicultural psychosocial intervention targeting symptom management in the context of advanced breast cancer","volume":"29","author":"Teo I","year":"2019","unstructured":"Teo I, , Plumb Vilardaga JC, , Tan TP, et al. A feasible and acceptable multicultural psychosocial intervention targeting symptom management in the context of advanced breast cancer. Palliat Med, 2019; 29:398\u2013397.","journal-title":"Palliat Med"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1200\/jco.23.00857"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1080\/17437199.2023.2261518"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcbs.2024.100810"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.31539"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijnurstu.2021.103876"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1111\/jan.15543"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1177\/02692163231183101"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-019-02312-8"},{"key":"e_1_3_3_56_2","volume-title":"The Brief Pain Inventory User Guide","author":"Cleeland CS","year":"2009","unstructured":"Cleeland CS. The Brief Pain Inventory User Guide. The University of Texas MD Anderson Cancer Center: Houston; 2009."},{"issue":"6","key":"e_1_3_3_57_2","first-page":"256","article-title":"Effect of a self-management program on patients with chronic disease","volume":"4","author":"Lorig KR","year":"2001","unstructured":"Lorig KR, , Sobel DS, , Ritter PL, et al. Effect of a self-management program on patients with chronic disease. Eff Clin Pract, 2001; 4(6):256\u2013262.","journal-title":"Eff Clin Pract"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.3390\/rel2010077"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1207\/S15324796ABM2401_06"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.beth.2011.03.007"},{"key":"e_1_3_3_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2019.112516"},{"key":"e_1_3_3_62_2","article-title":"Qualitative methods in rapid turn-around health services research","author":"Hamilton AB","year":"2013","unstructured":"Hamilton AB. Qualitative methods in rapid turn-around health services research. Evaluation Tools and Resources, 2013.","journal-title":"Evaluation Tools and Resources"},{"key":"e_1_3_3_63_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13012-019-0853-y"},{"key":"e_1_3_3_64_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2017-019993"},{"key":"e_1_3_3_65_2","doi-asserted-by":"publisher","DOI":"10.1097\/mlr.0000000000001553"},{"key":"e_1_3_3_66_2","doi-asserted-by":"publisher","DOI":"10.1177\/104973230201200611"},{"key":"e_1_3_3_67_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.30035"}],"container-title":["Journal of Adolescent and Young Adult Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/21565333261425871","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/21565333261425871","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/21565333261425871","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T05:17:41Z","timestamp":1793164661000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/21565333261425871"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,20]]},"references-count":66,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,12,1]]}},"alternative-id":["10.1177\/21565333261425871"],"URL":"https:\/\/doi.org\/10.1177\/21565333261425871","relation":{},"ISSN":["2156-5333","2156-535X"],"issn-type":[{"value":"2156-5333","type":"print"},{"value":"2156-535X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,20]]}}}