{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T05:45:17Z","timestamp":1777787117866,"version":"3.51.4"},"reference-count":37,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T00:00:00Z","timestamp":1774396800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Deutsche Stiftung Junge Erwachsene mit Krebs","award":["17\/10\/2022"],"award-info":[{"award-number":["17\/10\/2022"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Adolescent and Young Adult Oncology"],"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>While exercise oncology research has led to broad acceptance of exercise programs for cancer patients, the specific needs of young adults (YA) with cancer remain underexplored. The YOUEX study evaluates the effects of tailored online and in-person exercise programs on quality of life (QoL) and cancer-related fatigue (CRF) in YA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This three-arm, non-randomized, preference-based intervention study offered three exercise modules (M1) online supervised group-based, (M2) online unsupervised, and (M3) in-person supervised. YA with cancer (\u226439 years) participated in a 12-week intervention with a 12-week follow-up. QoL (EORTC QLQ-C30) and CRF (EORTC FA12, QLQ-C30 fatigue scale) were assessed at baseline (T0), 6 weeks (T1), 12 weeks (T2), and follow-up (T3).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      A total of 92 YA (mean age 31.9 \u00b1 4.9 years, 94% female) participated. M2 was most frequently chosen (54.3%), followed by M1 (34.8%) and M3 (10.9%). Overall QoL improved significantly at follow-up (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.01,\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      = 0.35). Significant improvements were observed in physical (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.001,\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      = 0.40), emotional (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.01,\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      = 0.36), cognitive (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.01,\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      = 0.34), and social functioning (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.01,\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      = 0.35) during the intervention, with continued physical and emotional improvements at follow-up. Fatigue symptoms decreased on the QLQ-C30 scale, while FA12 scales remained unchanged. No differences were found between modules.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Tailored exercise programs positively impact QoL in YA with cancer, with online interventions being particularly well received. Further research is needed to optimize these programs for CRF management and evaluate the effectiveness of online interventions in more detail.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/21565333261438093","type":"journal-article","created":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T05:40:04Z","timestamp":1774503604000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Longitudinal Effects of the YOUEX Exercise Intervention on Quality of Life and Cancer-Related Fatigue in Young Adults with Cancer"],"prefix":"10.1177","author":[{"given":"Annelie","family":"Voland","sequence":"first","affiliation":[{"name":"Department of Medical Oncology, Heidelberg University Hospital and National Center for Tumor Diseases Heidelberg, a partnership between German Cancer Research Center (DKFZ), University Medical Center Heidelberg, Heidelberg, Germany."},{"name":"Institute of Sports and Sports Science, Ruprecht Karls University of Heidelberg, Heidelberg, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2432-0343","authenticated-orcid":false,"given":"Verena","family":"Krell","sequence":"additional","affiliation":[{"name":"Department of Sports Medicine, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Berlin, Germany."},{"name":"Department of Sports Medicine, Institute of Sports Science, Humboldt-University zu Berlin, Berlin, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maximilian","family":"K\u00f6ppel","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Heidelberg University Hospital and National Center for Tumor Diseases Heidelberg, a partnership between German Cancer Research Center (DKFZ), University Medical Center Heidelberg, Heidelberg, Germany."},{"name":"Institute of Sports and Sports Science, Ruprecht Karls University of Heidelberg, Heidelberg, Germany."},{"name":"German Association for Health Sports and Sports Therapy (DVGS eV), H\u00fcrth-Efferen, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miriam","family":"G\u00f6tte","sequence":"additional","affiliation":[{"name":"West German Cancer Center, University Hospital Essen, Essen, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timo","family":"Sonntag","sequence":"additional","affiliation":[{"name":"Department I of Internal Medicine, Center of Integrated Oncology Aachen Bonn Cologne D\u00fcsseldorf, University Hospital of Cologne, Cologne, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joachim","family":"Wiskemann","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Heidelberg University Hospital and National Center for Tumor Diseases Heidelberg, a partnership between German Cancer Research Center (DKFZ), University Medical Center Heidelberg, Heidelberg, Germany."},{"name":"Institute of Sports and Sports Science, Ruprecht Karls University of Heidelberg, Heidelberg, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,3,25]]},"reference":[{"key":"e_1_3_5_2_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2018.0001"},{"key":"e_1_3_5_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.33793"},{"key":"e_1_3_5_4_1","doi-asserted-by":"publisher","DOI":"10.1089\/jayao.2018.0043"},{"key":"e_1_3_5_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2022.860729"},{"key":"e_1_3_5_6_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000002116"},{"key":"e_1_3_5_7_1","doi-asserted-by":"publisher","DOI":"10.3238\/arztebl.m2024.0038"},{"key":"e_1_3_5_8_1","doi-asserted-by":"publisher","DOI":"10.1249\/mss.0000000000001937"},{"key":"e_1_3_5_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/jncics\/pkz080"},{"key":"e_1_3_5_10_1","unstructured":"9.Deutsche Stiftung f\u00fcr junge Erwachsene mit Krebs. 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