{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T05:45:28Z","timestamp":1777787128022,"version":"3.51.4"},"reference-count":25,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:00:00Z","timestamp":1776729600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Adolescent and Young Adult Oncology"],"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>Nasopharyngeal carcinoma (NPC) is a rare cancer, especially in nonendemic regions such as North America, occurring in a bimodal age distribution with the first peak in adolescents and young adults (AYA). Limited data exist on treatment outcomes in this group. The purpose of our study is to evaluate treatment outcomes of NPC in the AYA population in British Columbia, Canada, and evaluate late effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We conducted a retrospective cohort study of AYA patients (ages of 15\u201339 years at diagnosis) diagnosed with NPC and treated between 2000 and 2015. Demographics, treatment outcomes, and late toxicities were collected. Overall survival (OS) and disease-free survival (DFS) were analyzed using the Kaplan\u2013Meier and Cox regression. Locoregional recurrence and distant metastatic recurrence were evaluated using the competing risk method. Late effects were described qualitatively and quantitatively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The cohort included 97 patients: 93 received curative intent treatment, 3 received palliative treatment, and 1 was excluded from survival analysis. Five-year OS rates were 81% (Stage I\/II), 80% (Stage III), and 68% (Stage IV), with corresponding DFS rates of 78%, 77%, and 66%. The addition of neoadjuvant and\/or adjuvant chemotherapy to radiotherapy was associated with improved survival. Advanced-stage disease had a higher incidence of locoregional relapse. Common late toxicities included xerostomia, hearing loss, epistaxis, and hypothyroidism.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Although survival rates in our cohort were comparable to existing literature, the rate of late toxicities was high. These findings support the need for AYA-tailored treatment strategies and survivorship care to minimize long-term complications and optimize quality of life.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/21565333261445411","type":"journal-article","created":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T12:01:02Z","timestamp":1776772862000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Treatment, Outcomes, and Late Effects in Adolescent and Young Adult Nasopharyngeal Carcinoma in a Provincial Population"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-7581-672X","authenticated-orcid":false,"given":"Sheila","family":"Hartstein","sequence":"first","affiliation":[{"name":"BC Cancer\u2014Vancouver Centre, Vancouver, Canada."},{"name":"University of British Columbia, Vancouver, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexa","family":"Dang","sequence":"additional","affiliation":[{"name":"BC Cancer\u2014Vancouver Centre, Vancouver, Canada."},{"name":"University of British Columbia, Vancouver, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Musoke","sequence":"additional","affiliation":[{"name":"BC Cancer\u2014Vancouver Centre, Vancouver, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daegan","family":"Sit","sequence":"additional","affiliation":[{"name":"BC Cancer\u2014Vancouver Centre, Vancouver, Canada."},{"name":"University of British Columbia, Vancouver, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Chan","sequence":"additional","affiliation":[{"name":"BC Cancer\u2014Vancouver Centre, Vancouver, Canada."},{"name":"University of British Columbia, Vancouver, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen","family":"Goddard","sequence":"additional","affiliation":[{"name":"BC Cancer\u2014Vancouver Centre, Vancouver, Canada."},{"name":"University of British Columbia, Vancouver, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole","family":"Chau","sequence":"additional","affiliation":[{"name":"BC Cancer\u2014Vancouver Centre, Vancouver, Canada."},{"name":"University of British Columbia, Vancouver, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonn","family":"Wu","sequence":"additional","affiliation":[{"name":"BC Cancer\u2014Vancouver Centre, Vancouver, Canada."},{"name":"University of British Columbia, Vancouver, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Berthelet","sequence":"additional","affiliation":[{"name":"BC Cancer\u2014Vancouver Centre, Vancouver, Canada."},{"name":"University of British Columbia, Vancouver, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Tran","sequence":"additional","affiliation":[{"name":"BC Cancer\u2014Vancouver Centre, Vancouver, Canada."},{"name":"University of British Columbia, Vancouver, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah Nicole","family":"Hamilton","sequence":"additional","affiliation":[{"name":"BC Cancer\u2014Vancouver Centre, Vancouver, Canada."},{"name":"University of British Columbia, Vancouver, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,4,21]]},"reference":[{"key":"e_1_3_2_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-024-10176-9"},{"key":"e_1_3_2_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)30956-0"},{"key":"e_1_3_2_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2019.01179"},{"key":"e_1_3_2_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12887-025-05653-1"},{"key":"e_1_3_2_6_1","doi-asserted-by":"publisher","DOI":"10.5505\/tjo.2023.4162"},{"key":"e_1_3_2_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.19.01276"},{"key":"e_1_3_2_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2013.10.020"},{"key":"e_1_3_2_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2021.105182"},{"key":"e_1_3_2_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2025.1895"},{"key":"e_1_3_2_11_1","doi-asserted-by":"publisher","DOI":"10.2340\/1651-226X.2025.43700"},{"key":"e_1_3_2_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-017-2401-y"},{"key":"e_1_3_2_13_1","doi-asserted-by":"publisher","DOI":"10.5732\/cjc.013.10124"},{"issue":"3","key":"e_1_3_2_14_1","article-title":"Updates on treatments and management of nasopharyngeal carcinoma","volume":"45","author":"Chua MLK","year":"2025","unstructured":"13.Chua MLK, , Zhang X, , Wong KCW, et al. Updates on treatments and management of nasopharyngeal carcinoma. Am Soc Clin Oncol Educ Book 2025;45(3).","journal-title":"Am Soc Clin Oncol Educ Book"},{"key":"e_1_3_2_15_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.10237"},{"key":"e_1_3_2_16_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.5420"},{"key":"e_1_3_2_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40880-016-0167-2"},{"key":"e_1_3_2_18_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.12544"},{"key":"e_1_3_2_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-024-12966-4"},{"key":"e_1_3_2_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-14-856"},{"key":"e_1_3_2_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2013.720"},{"key":"e_1_3_2_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13163956"},{"key":"e_1_3_2_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14051261"},{"issue":"7","key":"e_1_3_2_24_1","article-title":"The impact of survivorship care plans on adolescent and young adult head and neck cancer survivors and their primary care providers","volume":"31","author":"Hamilton SN","year":"2023","unstructured":"23.Hamilton SN, , Howard F, , Afghari N, et al. The impact of survivorship care plans on adolescent and young adult head and neck cancer survivors and their primary care providers. 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