{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T08:06:27Z","timestamp":1779005187380,"version":"3.51.4"},"reference-count":27,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:00:00Z","timestamp":1778716800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"crossref","award":["22EA2001"],"award-info":[{"award-number":["22EA2001"]}],"id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Adolescent and Young Adult Oncology"],"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Adolescent and young adult (AYA) patients with cancer face numerous challenges, particularly at the end-of-life. However, little is known about how the patients and their families experience end-of-life care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>We aimed to compare the quality of end-of-life palliative care and the levels of depression and grief among bereaved families of AYAs and middle-aged patients with cancer, and to identify associated factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We conducted a secondary analysis of a nationwide mortality follow-back survey based on death certificates of patients who died from cancer in 2017 and 2018. Subjects were classified into two groups AYA (aged 20\u201339 years) and the middle-aged (aged 40\u201364 years). End-of-life quality was evaluated using the Care Evaluation Scale, Good Death Inventory, and Memorial Symptom Assessment Scale. Depression and grief levels among bereaved family members were also evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      We analyzed 261 and 5790 bereaved families from the AYA and middle-aged groups, respectively. While the quality of end-of-life palliative care did not differ clinically significantly between the AYA and middle-aged group, the levels of grief and depression were significantly higher in the AYA compared with the middle-aged group (Effect Size [ES] = 0.57,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.0001; ES = 0.22,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.001, respectively).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Although end-of-life care quality was comparable between AYAs and middle-aged patients, bereaved families of AYA patients experienced significantly greater grief and depression. These findings underscore the need for tailored bereavement support for AYA families.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/21565333261450799","type":"journal-article","created":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T08:56:57Z","timestamp":1778749017000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Quality of End-of-Life Care for Adolescent and Young Adult Patients with Cancer and Depression and Grief in Bereaved Families: A Secondary Analysis"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7637-0409","authenticated-orcid":false,"given":"Mitsunori","family":"Miyashita","sequence":"first","affiliation":[{"name":"Department of Palliative Nursing, Health Sciences, Tohoku University Graduate School of Medicine, Sendai, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anni","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Palliative Nursing, Health Sciences, Tohoku University Graduate School of Medicine, Sendai, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satomi","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Palliative Nursing, Health Sciences, Tohoku University Graduate School of Medicine, Sendai, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Palliative Nursing, Health Sciences, Tohoku University Graduate School of Medicine, Sendai, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoko","family":"Nakazawa","sequence":"additional","affiliation":[{"name":"Division of Policy Evaluation, Institute for Cancer Control, National Cancer Center, Tokyo, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanori","family":"Mori","sequence":"additional","affiliation":[{"name":"Division of Palliative and Supportive Care, Seirei Mikatahara General Hospital, Hamamatsu, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chikako","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Breast and Medical Oncology, National Center for Global Health and Medicine, Japan Institute of Health Security, Tokyo, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,5,14]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21637"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.39.5467"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0885-3924(02)00440-2"},{"issue":"3","key":"e_1_3_3_5_1","first-page":"41","article-title":"Palliative care for adolescents and young adults with cancer","volume":"2013","author":"Rosenberg AR","year":"2013","unstructured":"4.Rosenberg AR, , and Wolfe J. Palliative care for adolescents and young adults with cancer. 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