{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T08:15:22Z","timestamp":1783066522759,"version":"3.54.6"},"reference-count":53,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Adolescent and Young Adult Oncology"],"abstract":"<jats:sec>\n                    <jats:title>Relevance:<\/jats:title>\n                    <jats:p>Adolescents and young adults (AYAs) diagnosed with cancer represent a particularly vulnerable group with unique developmental, psychosocial, and functional challenges. Beyond survival, improving health-related quality of life (HRQoL) has become a major priority in cancer survivorship and public health.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>This umbrella review aimed to critically synthesize evidence from existing systematic reviews and meta-analyses evaluating the effectiveness of physical, psychosocial, and mixed interventions for improving HRQoL and related health outcomes in AYA (e.g., cancer-related fatigue, anxiety, and physical functioning) cancer patients and survivors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A comprehensive search of PubMed\/MEDLINE, Web of Science, Cochrane Database of Systematic Reviews, and ScienceDirect identified eligible systematic reviews and meta-analyses published between 2015 and 2025.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Fifteen reviews were included. Physical activity interventions showed the most consistent moderate benefits, particularly in reducing fatigue and improving physical functioning and domain-specific HRQoL. Psychosocial interventions demonstrated small-to-moderate improvements in anxiety, depression, and emotional well-being. Mixed interventions showed promising but less robust evidence, particularly due to limited long-term follow-up. Overall evidence certainty ranged from low to moderate. Primary study redundancy was minimal (the corrected covered area = 1.7%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Psychosocial interventions, especially exercise-based and psychosocial programs, can improve key HRQoL domains in AYAs with cancer. However, more rigorous long-term studies are required, particularly for combined and digital approaches.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/21565333261464971","type":"journal-article","created":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T16:37:42Z","timestamp":1782751062000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Umbrella Review of Psychosocial, Physical, and Combined Interventions for Adolescents and Young Adults with Cancer: Impacts on Quality of Life and Health-Related Outcomes"],"prefix":"10.1177","author":[{"given":"Perizat","family":"Aitmaganbet","sequence":"first","affiliation":[{"name":"West Kazakhstan Marat Ospanov Medical University, Aqtobe, Kazakhstan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2712-3873","authenticated-orcid":false,"given":"Lunara","family":"Ishimova","sequence":"additional","affiliation":[{"name":"West Kazakhstan Marat Ospanov Medical University, Aqtobe, Kazakhstan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anar","family":"Tulyayeva","sequence":"additional","affiliation":[{"name":"West Kazakhstan Marat Ospanov Medical University, Aqtobe, Kazakhstan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maya","family":"Alibekova","sequence":"additional","affiliation":[{"name":"West Kazakhstan Marat Ospanov Medical University, Aqtobe, Kazakhstan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guldana","family":"Eskabylova","sequence":"additional","affiliation":[{"name":"West Kazakhstan Marat Ospanov Medical University, Aqtobe, Kazakhstan."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,6,29]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12062196"},{"issue":"1","key":"e_1_3_3_4_1","first-page":"111","article-title":"The relationship between cancer-related fatigue, quality of life and pain among cancer patients","volume":"10","author":"Liu D","year":"2023","unstructured":"3.Liu D, , Weng JS, , Ke X, et al. The relationship between cancer-related fatigue, quality of life and pain among cancer patients. Int J Nurs Sci 2023;10(1):111\u2013116.","journal-title":"Int J Nurs Sci"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/0284186X.2016.1266089"},{"issue":"3","key":"e_1_3_3_6_1","first-page":"309","article-title":"Psychosocial distress due to interference of normal developmental milestones in AYAs with cancer","volume":"9","author":"Itzep N","year":"2022","unstructured":"5.Itzep N, , Roth M. Psychosocial distress due to interference of normal developmental milestones in AYAs with cancer. Children (Basel). 2022;9(3):309.","journal-title":"Children (Basel)."},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-024-01623-9"},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2022.05.017"},{"key":"e_1_3_3_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29866"},{"key":"e_1_3_3_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-017-1520-x"},{"key":"e_1_3_3_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/children8111058"},{"key":"e_1_3_3_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.4886"},{"key":"e_1_3_3_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/08880018.2020.1712502"},{"key":"e_1_3_3_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-020-07175-8"},{"key":"e_1_3_3_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.27087"},{"key":"e_1_3_3_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11930-022-00343-w"},{"key":"e_1_3_3_17_1","doi-asserted-by":"publisher","DOI":"10.2196\/33239"},{"key":"e_1_3_3_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/20552076241310037"},{"key":"e_1_3_3_19_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.23.01465"},{"key":"e_1_3_3_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.6435"},{"key":"e_1_3_3_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.5577"},{"issue":"11","key":"e_1_3_3_22_1","first-page":"117","article-title":"Conducting psychosocial intervention research among adolescents and young adults with cancer: Lessons from the PRISM Randomized Clinical Trial","volume":"6","author":"Rosenberg AR","year":"2019","unstructured":"21.Rosenberg AR, , Junkins CC, , Sherr N, et al. Conducting psychosocial intervention research among adolescents and young adults with cancer: Lessons from the PRISM Randomized Clinical Trial. Children (Basel) 2019;6(11):117.","journal-title":"Children (Basel)"},{"key":"e_1_3_3_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2022.103620"},{"key":"e_1_3_3_24_1","doi-asserted-by":"publisher","DOI":"10.46658\/JBIMES-24-08"},{"key":"e_1_3_3_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.j4008"},{"key":"e_1_3_3_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39489.470347.AD"},{"key":"e_1_3_3_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2013.11.007"},{"key":"e_1_3_3_28_1","doi-asserted-by":"publisher","DOI":"10.1089\/jayao.2023.0047"},{"key":"e_1_3_3_29_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjsem-2022-001466"},{"key":"e_1_3_3_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-022-06854-5"},{"key":"e_1_3_3_31_1","doi-asserted-by":"publisher","DOI":"10.1177\/1534735419895590"},{"key":"e_1_3_3_32_1","doi-asserted-by":"publisher","DOI":"10.1089\/jayao.2023.0150"},{"key":"e_1_3_3_33_1","doi-asserted-by":"publisher","DOI":"10.1089\/jayao.2019.0013"},{"key":"e_1_3_3_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11764-016-0527-6"},{"key":"e_1_3_3_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2021.103291"},{"key":"e_1_3_3_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2023.104045"},{"key":"e_1_3_3_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.70081"},{"key":"e_1_3_3_38_1","doi-asserted-by":"publisher","DOI":"10.3390\/healthcare13101094"},{"key":"e_1_3_3_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11764-025-01836-y"},{"issue":"6","key":"e_1_3_3_40_1","first-page":"342","article-title":"Interventions about physical activity and diet and their impact on adolescent and young adult cancer survivors: A Prisma systematic review","volume":"32","author":"Vasilopoulou M","year":"2024","unstructured":"39.Vasilopoulou M, , Asimakopoulou Z, , Velissari J, et al. Interventions about physical activity and diet and their impact on adolescent and young adult cancer survivors: A Prisma systematic review. Support Care Cancer. 2024;32(6):342.","journal-title":"Support Care Cancer."},{"key":"e_1_3_3_41_1","doi-asserted-by":"publisher","DOI":"10.1089\/jayao.2021.0012"},{"key":"e_1_3_3_42_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2021.784615"},{"key":"e_1_3_3_43_1","doi-asserted-by":"publisher","DOI":"10.1186\/s41687-023-00629-0"},{"key":"e_1_3_3_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.invent.2025.100824"},{"key":"e_1_3_3_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.5987"},{"key":"e_1_3_3_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.70234"},{"key":"e_1_3_3_47_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOP.0000000000001200"},{"key":"e_1_3_3_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.31664"},{"key":"e_1_3_3_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.35182"},{"key":"e_1_3_3_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.33155"},{"key":"e_1_3_3_51_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djac166"},{"key":"e_1_3_3_52_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2018.0001"},{"key":"e_1_3_3_53_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2023.0040"},{"key":"e_1_3_3_54_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.23.02240"}],"container-title":["Journal of Adolescent and Young Adult Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/21565333261464971","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/21565333261464971","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/21565333261464971","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T07:16:57Z","timestamp":1783063017000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/21565333261464971"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,29]]},"references-count":53,"alternative-id":["10.1177\/21565333261464971"],"URL":"https:\/\/doi.org\/10.1177\/21565333261464971","relation":{},"ISSN":["2156-5333","2156-535X"],"issn-type":[{"value":"2156-5333","type":"print"},{"value":"2156-535X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,29]]},"article-number":"21565333261464971"}}