{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T12:08:40Z","timestamp":1789042120187,"version":"build-2803163510"},"reference-count":54,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T00:00:00Z","timestamp":1788652800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Adolescent and Young Adult Oncology"],"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Outcomes among the Hispanic population are rarely explored in adolescents and young adults (AYAs). We aimed to compare sociodemographic, clinical, and survival outcomes of Latin American AYAs (\u226439 years) with middle-aged (40\u201359 years) and older (\u226560 years) patients with melanoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A single-center retrospective cohort study among patients with melanoma stages I\u2013IV was conducted in Lima, Peru, from 2010 to 2019. We evaluated overall survival (OS), event-free survival (EFS) rates, and prognostic factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Of 1121 patients with melanoma, 118 (10.5%) were AYAs, 357 (31.9%) were middle-aged, and 645 (57.6%) were elderly. Less frequencies of lower extremity as primary site (56.8%, 68.9%, and 82.3%,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.01), ulceration (46.8%, 58.8%, 72.5%,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.01), and acral histology (22.6%, and 32.8%, and 44.3%,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.01) were present in AYAs. Moreover, AYAs had a higher frequency of American Joint Committee on Cancer stages I (16.1%, 10.1%, and 7.9%) and IV (25.4%, 24.6%, and 21.9%,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.01). AYAs had less frequent adjuvant chemotherapy (10.3%, 18.4%, and 11.2%,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.03). With a median follow-up of 9.8 years, the 5-year OS and EFS rates for AYAs (52%, 32%) were better than the middle-aged (43%, 23%) and older population (32%, 15%) (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.01). Multivariate analyses showed that AYAs had better prognosis than elderly population (\u226560 years, hazard ratio = 1.93).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Latin American AYAs with melanoma had less aggressive tumor characteristics and received less systemic therapy compared to middle-aged patients, yet demonstrated better EFS and OS rates across all age groups. Therefore, younger age is not a risk factor for worse survival outcomes. Given the relatively high frequency of stage IV disease in AYAs, it is crucial to develop strategies for early detection in the primary care setting.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/21565333261485759","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T02:43:01Z","timestamp":1788748981000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Characteristics and Outcomes of Melanoma Among Latin American Adolescents and Young Adults Compared to Middle-Aged and Elderly Population: A Cohort Analysis Over 10 Years"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4203-3890","authenticated-orcid":false,"given":"Gabriel","family":"De la Cruz Ku","sequence":"first","affiliation":[{"name":"Universidad Cient\u00edfica del Sur, Lima, Peru."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anshumi","family":"Desai","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Piedra Delgado","sequence":"additional","affiliation":[{"name":"Universidad Cient\u00edfica del Sur, Lima, Peru."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Mallouh","sequence":"additional","affiliation":[{"name":"University of Massachusetts Medical School, Worcester, Massachusetts, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Gonzales","sequence":"additional","affiliation":[{"name":"Universidad Cient\u00edfica del Sur, Lima, Peru."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiddu","family":"Guart","sequence":"additional","affiliation":[{"name":"University of Massachusetts Medical School, Worcester, Massachusetts, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kabir","family":"Torres","sequence":"additional","affiliation":[{"name":"University of Massachusetts Medical School, Worcester, Massachusetts, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila","family":"Franco","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Texas Medical Branch at Galveston, Galveston, Texas, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo","family":"Chavez Diaz","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery, Hospital Nacional Guillermo Almenara Irigoyen, Lima, Peru."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gonzalo","family":"Ziegler","sequence":"additional","affiliation":[{"name":"Clinica Ziegler, Lima, Peru."},{"name":"Department of Surgical Oncology, Instituto Nacional de Enfermedades Neoplasicas, Lima, Peru."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,9,6]]},"reference":[{"key":"e_1_3_4_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2022.0160"},{"key":"e_1_3_4_3_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-024-16062-6"},{"key":"e_1_3_4_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/CMR.0000000000000959"},{"key":"e_1_3_4_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-023-00795-3"},{"key":"e_1_3_4_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpt.2024.08.002"},{"key":"e_1_3_4_7_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0102-311X2011000300016"},{"key":"e_1_3_4_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2016.02.005"},{"key":"e_1_3_4_9_1","unstructured":"8.Registro de Cancer de Lima Metropolitana. 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