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These groups were treated during 21 days with topical placebo or a cream based on BFR.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results.<\/jats:title>\n                    <jats:p>\n                      Significant improvements were observed on self-reported symptom severity and pain intensity favorable to BFR groups with large effect sizes (\u03b7\n                      <jats:sup>2<\/jats:sup>\n                      <jats:sub>partial<\/jats:sub>\n                      &gt; 0.40). In addition, all signs observed during the clinical exam showed significant improvements among the groups as well as symptoms of pain, night pain, and tingling, also with large effect sizes (\u03c6 &gt; 0.5). Finally, there were significant differences between the\n                      <jats:italic toggle=\"yes\">blinded<\/jats:italic>\n                      and\n                      <jats:italic toggle=\"yes\">nonblinded<\/jats:italic>\n                      BFR groups for signs and pain registered in clinical exam but not in self-reports.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion.<\/jats:title>\n                    <jats:p>The proposed BFR cream could be an effective intervention in the management of mild and moderate carpal tunnel syndrome, reducing the severity symptoms and providing pain relief.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/2156587215610705","type":"journal-article","created":{"date-parts":[[2015,10,12]],"date-time":"2015-10-12T17:32:05Z","timestamp":1444671125000},"page":"18-24","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Exploring the Effectiveness of External Use of Bach Flower Remedies on Carpal Tunnel Syndrome"],"prefix":"10.1177","volume":"22","author":[{"given":"Saira R.","family":"Rivas-Su\u00e1rez","sequence":"first","affiliation":[{"name":"Medical University \u201cSeraf\u00edn Ru\u00edz de Z\u00e1rate Ru\u00edz\u201d of Villa Clara, Santa Clara, Cuba"},{"name":"University Hospital \u201cArnaldo Mili\u00e1n Castro,\u201d Santa Clara, Cuba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime","family":"\u00c1guila-V\u00e1zquez","sequence":"additional","affiliation":[{"name":"University Hospital \u201cArnaldo Mili\u00e1n Castro,\u201d Santa Clara, Cuba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e1rbara","family":"Su\u00e1rez-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"University Hospital \u201cArnaldo Mili\u00e1n Castro,\u201d Santa Clara, Cuba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e1zaro","family":"V\u00e1zquez-Le\u00f3n","sequence":"additional","affiliation":[{"name":"University Hospital \u201cArnaldo Mili\u00e1n Castro,\u201d Santa Clara, Cuba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarita","family":"Casanova-Giral","sequence":"additional","affiliation":[{"name":"University Hospital \u201cArnaldo Mili\u00e1n Castro,\u201d Santa Clara, Cuba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Morales-Morales","sequence":"additional","affiliation":[{"name":"University Hospital \u201cArnaldo Mili\u00e1n Castro,\u201d Santa Clara, Cuba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris C.","family":"Rodr\u00edguez-Mart\u00edn","sequence":"additional","affiliation":[{"name":"Central University \u201cMarta Abreu\u201d of Las Villas, Santa Clara, Cuba"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,6,23]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.homp.2010.05.006"},{"key":"e_1_3_2_3_2","first-page":"202","article-title":"Nonlinear effect of nanoparticles: biological variability from hormetic doses, small particles sizes, and dynamic adaptive interactions","volume":"12","author":"Bell IR","year":"2013","unstructured":"Bell IR, Ives JA, Jonas WB. 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