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The present study evaluates the efficacy of aqueous extract of Prosopis farcta root on experimental atherosclerosis development in rabbits with high cholesterol diet\u2013induced hypercholesterolemia. Serum lipid parameters were significantly increased in the high cholesterol diet groups in comparison with the normal control group ( P &lt; .050). Histopathological findings revealed that atheromatous plaques were formed in both thoracic and abdominal aorta of hypercholestrolemic rabbits. Treatment with Prosopis farcta root significantly reduced total cholesterol, triglyceride, high-density lipoprotein, low-density lipoprotein, and very low density lipoprotein levels compared to high cholesterol diet rabbits ( P &lt; .050). This finding may reflect a reduction of chest pain or the beneficial effects of this plant root extract on cardiovascular health. The present study can serve as a basis for future investigations on the other effects of this plant on cardiovascular health.<\/jats:p>","DOI":"10.1177\/2156587215627552","type":"journal-article","created":{"date-parts":[[2016,1,22]],"date-time":"2016-01-22T20:10:58Z","timestamp":1453493458000},"page":"NP62-NP66","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Antihyperlipidemic Effect of Syrian Mesquite (\n                    <i>Prosopis farcta<\/i>\n                    ) Root in High Cholesterol Diet\u2013Fed Rabbits"],"prefix":"10.1177","volume":"21","author":[{"given":"Mohammad Reza","family":"Saidi","sequence":"first","affiliation":[{"name":"Imam Ali Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad Hosein","family":"Farzaei","sequence":"additional","affiliation":[{"name":"Medical Biology Research Center, 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