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The purpose of this study was to find out new scientific evidence in modern medicine about their recommendations, in order to find certain clues to conduct useful researches in the future. First, treatments of anal fissure mentioned by Razi and Ibn Sina were reviewed. Then, literature search was made in electronic databases including PubMed, Scopus, and Google Scholar. Management of anal fissure according to Razi\u2019s and Ibn Sina\u2019s practices is done based on 3 interventions: lifestyle modifications, drug treatments, and manual procedures. Almost all remedies suggested by Razi and Ibn Sina have shown their effects on fissure in ano via several mechanisms of action in many in vitro and in vivo studies; Still there is lack of human studies on the subject.<\/jats:p>","DOI":"10.1177\/2156587216650302","type":"journal-article","created":{"date-parts":[[2016,6,8]],"date-time":"2016-06-08T20:49:35Z","timestamp":1465418975000},"page":"324-333","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["Natural Treatments for Fissure in Ano Used by Traditional Persian Scholars, Razi (Rhazes) and Ibn Sina (Avicenna)"],"prefix":"10.1177","volume":"22","author":[{"given":"Ali Reza","family":"Derakhshan","sequence":"first","affiliation":[{"name":"Shahid Beheshti University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,6,23]]},"reference":[{"key":"bibr1-2156587216650302","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2006.02990.x"},{"key":"bibr2-2156587216650302","doi-asserted-by":"publisher","DOI":"10.1016\/S1015-9584(08)60078-0"},{"key":"bibr3-2156587216650302","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1318.2006.01185.x"},{"key":"bibr4-2156587216650302","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2004.01886.x"},{"key":"bibr5-2156587216650302","first-page":"143","volume":"15","author":"Liratzopoulos N","year":"2006","journal-title":"J Gastrointest Liver Dis"},{"key":"bibr6-2156587216650302","first-page":"624","volume":"85","author":"Fargo MV","year":"2012","journal-title":"Am Fam Physician"},{"key":"bibr7-2156587216650302","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1272820"},{"key":"bibr8-2156587216650302","first-page":"550","volume":"11","author":"Hosseini SV","year":"2008","journal-title":"Arch Iran Med"},{"key":"bibr9-2156587216650302","first-page":"30","volume":"105","author":"Gupta PJ","year":"2004","journal-title":"Bratisl Lek Listy"},{"key":"bibr10-2156587216650302","doi-asserted-by":"publisher","DOI":"10.1007\/s12262-011-0239-0"},{"key":"bibr11-2156587216650302","doi-asserted-by":"publisher","DOI":"10.4240\/wjgs.v2.i7.231"},{"key":"bibr12-2156587216650302","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/565279"},{"key":"bibr13-2156587216650302","first-page":"253","volume":"7","author":"Tao ZG","year":"2013","journal-title":"Biosci Trends"},{"key":"bibr14-2156587216650302","volume-title":"Harrison\u2019s Principles of Internal Medicine","author":"Briggs JP","year":"2012","edition":"18"},{"key":"bibr15-2156587216650302","first-page":"93","volume":"7","author":"Pourahmad J","year":"2008","journal-title":"Iran J Pharm Res"},{"key":"bibr16-2156587216650302","doi-asserted-by":"publisher","DOI":"10.1016\/S0254-6272(11)60006-X"},{"key":"bibr17-2156587216650302","first-page":"1084","volume-title":"Al-Hawi fi al-tibb","volume":"11","author":"ABMiZ Razi","year":"2002"},{"key":"bibr18-2156587216650302","first-page":"88","volume-title":"Kamel-al-Sanaat al-Tibbiah (The Perfect Art of Medicine)","volume":"4","author":"Majusi Ahwazi A","year":"2008"},{"key":"bibr19-2156587216650302","first-page":"525","volume-title":"Al-qanoon fi al-teb","volume":"3","author":"Sina Ibn","year":"1593"},{"key":"bibr20-2156587216650302","first-page":"716","volume-title":"Zakhirah-i Khvarazm\u2019Shahi","volume":"2","author":"Jorjani SI","year":"2012"},{"key":"bibr21-2156587216650302","unstructured":"Nafis Ibn. shiqaq al-maq\u2019adah. 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