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Anti-HSV-1 activity was evaluated on baby hamster kidney cell line using MTT assay. The inhibitory effect of the plant materials on adsorption and\/or post-adsorption stages of HSV-1 replication cycle were determined. Regression analysis was used to determine 50% inhibitory concentration and 50% cytotoxicity concentration, from which selective index was calculated. Based on our results, the chloroform fraction and the crude extract had the highest effect against HSV-1 with selectivity indices of 53.8 and 48.4, respectively. The n-hexane, n-butanol, and chloroform fractions inhibited HSV-1 replication in postadsorption stage ( P &lt; .001). The results obtained indicated that the chloroform fraction of Q brantii acorn with high inhibitory effect against HSV-1 replication could be a new promising anti-HSV-1 agent.<\/jats:p>","DOI":"10.1177\/2156587216676421","type":"journal-article","created":{"date-parts":[[2016,11,29]],"date-time":"2016-11-29T23:38:18Z","timestamp":1480462698000},"page":"455-461","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":21,"title":["Anti\u2013Herpes Simplex Virus Type-1 Activity and Phenolic Content of Crude Ethanol Extract and Four Corresponding Fractions of\n                    <i>Quercus brantii<\/i>\n                    L Acorn"],"prefix":"10.1177","volume":"22","author":[{"given":"Ali","family":"Karimi","sequence":"first","affiliation":[{"name":"Medical Plants Research Center, Shahrekord University of Medical Science, Shahrekord, 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