{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T21:32:34Z","timestamp":1777498354946,"version":"3.51.4"},"reference-count":44,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Evid Based Complementary Altern Med"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:p>This study compared the therapeutic effect of flax seed oil topical gel and hand splint in the treatment of carpal tunnel syndrome. This study was a randomized clinical trial. Forty-nine patients, 96 hands, with mild to moderate idiopathic carpal tunnel syndrome were divided into 2 groups randomly. One group was treated by topical gel and the other group by hand splint. Intensity of symptoms and function before and after intervention was measured via Boston Carpal Tunnel Questionnaire. After intervention, the ANCOVA showed a significant difference between the symptom and function scores of the 2 groups. In both cases, recovery was higher in the gel group ( P &lt; .001). The topical use of flax seed oil gel is more effective in the improvement of symptoms and function of patients with mild to moderate carpal tunnel syndrome as compared with hand splint, and it can be introduced as an effective treatment.<\/jats:p>","DOI":"10.1177\/2156587216677822","type":"journal-article","created":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T21:10:41Z","timestamp":1480626641000},"page":"462-467","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["A Topical Gel From Flax Seed Oil Compared With Hand Splint in Carpal Tunnel Syndrome: A Randomized Clinical Trial"],"prefix":"10.1177","volume":"22","author":[{"given":"Mohammad","family":"Setayesh","sequence":"first","affiliation":[{"name":"School of Traditional Medicine, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amir Reza","family":"Sadeghifar","sequence":"additional","affiliation":[{"name":"Kerman University of Medical Sciences, Kerman, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nozar","family":"Nakhaee","sequence":"additional","affiliation":[{"name":"Kerman University of Medical Sciences, Kerman, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad","family":"Kamalinejad","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hossein","family":"Rezaeizadeh","sequence":"additional","affiliation":[{"name":"School of Traditional Medicine, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2016,12,1]]},"reference":[{"key":"bibr1-2156587216677822","doi-asserted-by":"publisher","DOI":"10.2174\/1874325001206010069"},{"key":"bibr2-2156587216677822","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhsa.2014.05.024"},{"key":"bibr3-2156587216677822","volume-title":"Clinical Guideline on Diagnosis of Carpal Tunnel Syndrome","author":"American Academy of Orthopaedic Surgeons","year":"2007"},{"key":"bibr4-2156587216677822","doi-asserted-by":"publisher","DOI":"10.1001\/jama.282.2.153"},{"key":"bibr5-2156587216677822","doi-asserted-by":"publisher","DOI":"10.1007\/s00776-009-1416-x"},{"key":"bibr6-2156587216677822","first-page":"6","volume":"77","author":"Aroori S","year":"2008","journal-title":"Ulster Med J"},{"key":"bibr7-2156587216677822","doi-asserted-by":"publisher","DOI":"10.5435\/00124635-200709000-00004"},{"key":"bibr8-2156587216677822","first-page":"36","volume":"57","author":"Bongers FJ","year":"2007","journal-title":"Br J Gen Pract"},{"key":"bibr9-2156587216677822","doi-asserted-by":"publisher","DOI":"10.5271\/sjweh.3351"},{"key":"bibr10-2156587216677822","doi-asserted-by":"publisher","DOI":"10.1016\/0895-4356(92)90038-O"},{"key":"bibr11-2156587216677822","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.58.2.289"},{"key":"bibr12-2156587216677822","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-009-0213-9"},{"key":"bibr13-2156587216677822","doi-asserted-by":"publisher","DOI":"10.3233\/WOR-2012-0745-4450"},{"key":"bibr14-2156587216677822","doi-asserted-by":"publisher","DOI":"10.1007\/s11552-010-9263-y"},{"key":"bibr15-2156587216677822","doi-asserted-by":"publisher","DOI":"10.2519\/jospt.2004.34.10.565"},{"key":"bibr16-2156587216677822","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2011.01.014"},{"key":"bibr17-2156587216677822","doi-asserted-by":"publisher","DOI":"10.1016\/S1388-2457(02)00169-4"},{"key":"bibr18-2156587216677822","doi-asserted-by":"publisher","DOI":"10.1177\/0269215507077294"},{"key":"bibr19-2156587216677822","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2010.03.022"},{"key":"bibr20-2156587216677822","volume-title":"WHO Traditional Medicine Strategy 2002-2005","author":"World Health Organization","year":"2002"},{"key":"bibr21-2156587216677822","doi-asserted-by":"publisher","DOI":"10.1177\/2156587214555714"},{"issue":"1","key":"bibr22-2156587216677822","first-page":"169","volume":"38","author":"Rezaeizadeh H","year":"2009","journal-title":"Iran J Public Health"},{"issue":"1","key":"bibr23-2156587216677822","first-page":"9","volume":"13","author":"Heydari M","year":"2015","journal-title":"Acta Med Hist Adriat"},{"key":"bibr24-2156587216677822","volume-title":"Al-Qanun fit-tib [The Canon of Medicine]","author":"Avicenna H","year":"2005"},{"key":"bibr25-2156587216677822","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctcp.2015.06.003"},{"key":"bibr26-2156587216677822","doi-asserted-by":"publisher","DOI":"10.3109\/13880209.2013.777462"},{"key":"bibr27-2156587216677822","unstructured":"Aazam M. Exire-azam. In: Tafaghod R. 1st ed. Tehran, Iran: Al-maei; 2014:435\u2013439."},{"key":"bibr28-2156587216677822","doi-asserted-by":"publisher","DOI":"10.1186\/2008-2231-22-43"},{"key":"bibr29-2156587216677822","first-page":"932","volume":"49","author":"Kaithwas G","year":"2011","journal-title":"Indian J Exp Biol"},{"key":"bibr30-2156587216677822","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/136.6.1545"},{"key":"bibr31-2156587216677822","doi-asserted-by":"publisher","DOI":"10.1002\/biof.5520130129"},{"key":"bibr32-2156587216677822","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.3535"},{"key":"bibr33-2156587216677822","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/735158"},{"key":"bibr34-2156587216677822","doi-asserted-by":"publisher","DOI":"10.2174\/187153012802002901"},{"key":"bibr35-2156587216677822","doi-asserted-by":"publisher","DOI":"10.1007\/s00402-010-1150-z"},{"key":"bibr36-2156587216677822","doi-asserted-by":"publisher","DOI":"10.1097\/00002060-199711000-00004"},{"key":"bibr37-2156587216677822","doi-asserted-by":"publisher","DOI":"10.4103\/0972-2327.120495"},{"key":"bibr38-2156587216677822","doi-asserted-by":"publisher","DOI":"10.1097\/PHM.0b013e31822409cf"},{"key":"bibr39-2156587216677822","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2474-7-78"},{"key":"bibr41-2156587216677822","doi-asserted-by":"publisher","DOI":"10.2137\/145960606780061443"},{"key":"bibr42-2156587216677822","doi-asserted-by":"publisher","DOI":"10.1002\/jor.21163"},{"key":"bibr43-2156587216677822","author":"Rivas-Su\u00e1rez SR","journal-title":"J Evid Based Complementary Altern Med"},{"key":"bibr44-2156587216677822","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctcp.2015.08.001"},{"key":"bibr45-2156587216677822","doi-asserted-by":"publisher","DOI":"10.1177\/2156587214542006"}],"container-title":["Journal of Evidence-Based Complementary &amp; Alternative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2156587216677822","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2156587216677822","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2156587216677822","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T15:09:22Z","timestamp":1777388962000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.sagepub.com\/doi\/10.1177\/2156587216677822"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,1]]},"references-count":44,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["10.1177\/2156587216677822"],"URL":"https:\/\/doi.org\/10.1177\/2156587216677822","relation":{},"ISSN":["2156-5872","2156-5899"],"issn-type":[{"value":"2156-5872","type":"print"},{"value":"2156-5899","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,1]]}}}