{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T04:34:27Z","timestamp":1777523667758,"version":"3.51.4"},"reference-count":13,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2016,12,22]],"date-time":"2016-12-22T00:00:00Z","timestamp":1482364800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Evid Based Complementary Altern Med"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:p>Asthma is a common respiratory disease characterized by airway inflammation, airway hyperreactivity, and reversible airflow obstruction. Despite current treatments, the prevalence of asthma has increased markedly over decades. According to the theories proposed to explain the pathophysiology of autoimmune diseases in integrative medicine, leaky gut syndrome is a phenomenon of increased intestinal permeability due to the disruption of tight junctions and is thought to be related to many chronic diseases, such as food intolerance, inflammatory bowel disease, rheumatoid arthritis, asthma, and other autoimmune disease. One of the classical approaches used by integrative physicians to treat leaky gut syndrome is to repair intestinal permeability to prevent allergic cascade. Due to several mechanisms that have been mentioned in the protective effects of plant gums and plantain family seeds on the intestinal epithelium, we can propose an effective management for leaky gut syndrome to treat asthma.<\/jats:p>","DOI":"10.1177\/2156587216682169","type":"journal-article","created":{"date-parts":[[2017,1,11]],"date-time":"2017-01-11T02:27:54Z","timestamp":1484101674000},"page":"378-380","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["A Viewpoint on the Leaky Gut Syndrome to Treat Allergic Asthma: A Novel Opinion"],"prefix":"10.1177","volume":"22","author":[{"given":"Masoumeh Kaboli","family":"Farshchi","sequence":"first","affiliation":[{"name":"School of Persian and Complementary Medicine, Mashhad University of Medical Sciences, Mashhad, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farahzad Jabbari","family":"Azad","sequence":"additional","affiliation":[{"name":"Department of Immunology and Allergy, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roshanak","family":"Salari","sequence":"additional","affiliation":[{"name":"Department of traditonal persian Pharmacy, School of Persian and Complementary Medicine, Mashhad University of Medical Sciences, Mashhad, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Majid","family":"Mirsadraee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Islamic Azad University, Mashhad Branch, Mashhad, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Majid","family":"Anushiravani","sequence":"additional","affiliation":[{"name":"School of Persian and Complementary Medicine, Mashhad University of Medical Sciences, Mashhad, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2016,12,22]]},"reference":[{"key":"bibr1-2156587216682169","volume-title":"Andreoli and Carpenter\u2019s Cecil Essentials of Medicine","author":"Benjamin I","year":"2010"},{"key":"bibr2-2156587216682169","volume-title":"Middleton\u2019s Allergy: Principles and Practice","author":"Adkinson NF","year":"2009"},{"key":"bibr3-2156587216682169","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2003.027680"},{"key":"bibr4-2156587216682169","doi-asserted-by":"publisher","DOI":"10.1080\/20786204.2010.10873997"},{"key":"bibr5-2156587216682169","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2013.07.001"},{"key":"bibr6-2156587216682169","volume-title":"Integrative Gastroenterology","author":"Mullin G","year":"2011"},{"key":"bibr7-2156587216682169","first-page":"22","volume":"10","author":"Kiefer D","year":"2004","journal-title":"Altern Ther Health Med"},{"key":"bibr8-2156587216682169","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2005.tb01904.x"},{"key":"bibr10-2156587216682169","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.nutr.23.011702.073036"},{"key":"bibr11-2156587216682169","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3444"},{"key":"bibr12-2156587216682169","volume-title":"The Constituents of Medicinal Plants: An Introduction to the Chemistry and Therapeutics of Herbal Medicine","author":"Pengelly A","year":"2004"},{"key":"bibr13-2156587216682169","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-015-0827-9"},{"key":"bibr14-2156587216682169","doi-asserted-by":"publisher","DOI":"10.4103\/0974-8490.81959"}],"container-title":["Journal of Evidence-Based Complementary &amp; Alternative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2156587216682169","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2156587216682169","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2156587216682169","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T15:09:23Z","timestamp":1777388963000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.sagepub.com\/doi\/10.1177\/2156587216682169"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,22]]},"references-count":13,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["10.1177\/2156587216682169"],"URL":"https:\/\/doi.org\/10.1177\/2156587216682169","relation":{},"ISSN":["2156-5872","2156-5899"],"issn-type":[{"value":"2156-5872","type":"print"},{"value":"2156-5899","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,22]]}}}