{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T21:33:39Z","timestamp":1777498419798,"version":"3.51.4"},"reference-count":35,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2017,7,18]],"date-time":"2017-07-18T00:00:00Z","timestamp":1500336000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Evid Based Complementary Altern Med"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:p>Tetracarpidium conophorum leaves are used in traditional medicine for the treatment of male infertility, without considering its toxicity and side effects. In this study, we investigated the effects of T conophorum leaves on some biochemical parameters such as alanine aminotransferase, aspartate aminotransferase, bilirubin, albumin, creatinine, and uric acid. Histology of the liver and kidney were also assessed. The result revealed that the alanine aminotransferase and aspartate aminotransferase levels of the control group were not significantly different from the experimental groups. There was no significant difference in the albumin and bilirubin levels of the control and experimental groups. Similarly, the uric acid and creatinine levels of the experimental rats were not significantly different from the control. The examination of liver and kidney sections did not show any morphological changes and inflammatory cell infiltrations. These findings suggest that the leaves did not induce any pathological changes at the doses tested.<\/jats:p>","DOI":"10.1177\/2156587217718979","type":"journal-article","created":{"date-parts":[[2017,7,20]],"date-time":"2017-07-20T12:25:30Z","timestamp":1500553530000},"page":"919-925","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Toxicological Effects of Aqueous Extract From African Walnut (\n                    <i>Tetracarpidium conophorum<\/i>\n                    ) Leaves in Rats"],"prefix":"10.1177","volume":"22","author":[{"given":"Seun F.","family":"Akomolafe","sequence":"first","affiliation":[{"name":"Ekiti State University, Ado Ekiti, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ganiyu","family":"Oboh","sequence":"additional","affiliation":[{"name":"Federal University of Technology, Akure, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunday I.","family":"Oyeleye","sequence":"additional","affiliation":[{"name":"Federal University of Technology, Akure, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tosin A.","family":"Olasehinde","sequence":"additional","affiliation":[{"name":"Federal Institute of Industrial Research, Lagos, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,7,18]]},"reference":[{"issue":"2","key":"bibr1-2156587217718979","first-page":"86","volume":"3","author":"Okigbo RN","year":"2009","journal-title":"J Med Plants Res"},{"key":"bibr2-2156587217718979","first-page":"12","volume":"3","author":"Gupta M","year":"2004","journal-title":"Iran J Pharmacol Ther"},{"key":"bibr3-2156587217718979","first-page":"189","volume":"10","author":"D\u2019Arcy PF.","year":"1991","journal-title":"Adverse Drug React Toxicol Rev"},{"key":"bibr4-2156587217718979","doi-asserted-by":"publisher","DOI":"10.1016\/S0367-326X(02)00285-X"},{"key":"bibr5-2156587217718979","doi-asserted-by":"publisher","DOI":"10.3923\/pjn.2006.102.105"},{"key":"bibr6-2156587217718979","volume-title":"Leaf Protein Research in Nigeria","author":"Oke OL","year":"1995"},{"key":"bibr7-2156587217718979","volume-title":"Outlines and Pictures of Medicinal Plants From Nigeria","author":"Odugbemi O","year":"2008"},{"key":"bibr8-2156587217718979","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-015-0547-1"},{"key":"bibr9-2156587217718979","first-page":"93","volume":"22","author":"Oladiji AT","year":"2007","journal-title":"Nigerian J Biochem Mol Biol"},{"key":"bibr10-2156587217718979","unstructured":"Organization for Economic and Cultural Development. Acute Oral Toxicity\u2014Up and Down Procedure: Guidelines for Testing of Chemicals. https:\/\/ntp.niehs.nih.gov\/iccvam\/suppdocs\/feddocs\/oecd\/oecd_gl425-508.pdf. Accessed June 27, 2017."},{"key":"bibr11-2156587217718979","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(71)90365-2"},{"key":"bibr12-2156587217718979","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/28.1.56"},{"key":"bibr13-2156587217718979","first-page":"81","volume":"297","author":"Jendrasick J","year":"1938","journal-title":"Zur Bestimmury des Blulbiliruin Biochem"},{"key":"bibr14-2156587217718979","unstructured":"Sherlock S. Liver Disease: Determination of Total Direct Bilirubin, Colorimetric Method. London, England: Churchill; 1951:530."},{"key":"bibr15-2156587217718979","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1021\/ac60155a056","volume":"31","author":"Collin PF","year":"1959","journal-title":"J Ann Chem"},{"key":"bibr16-2156587217718979","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/60.5.691"},{"key":"bibr17-2156587217718979","volume-title":"Clinical Chemistry, Principles and Techniques","author":"Henry RJ","year":"1974"},{"key":"bibr18-2156587217718979","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)52451-6"},{"key":"bibr19-2156587217718979","doi-asserted-by":"publisher","DOI":"10.3923\/jpt.2007.373.379"},{"key":"bibr20-2156587217718979","volume-title":"A Textbook of Pharmacognosy","author":"Trease CE","year":"1989","edition":"13"},{"key":"bibr21-2156587217718979","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(99)99017-1"},{"key":"bibr22-2156587217718979","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2004.10.006"},{"key":"bibr23-2156587217718979","doi-asserted-by":"publisher","DOI":"10.9734\/ARRB\/2014\/5426"},{"key":"bibr24-2156587217718979","doi-asserted-by":"publisher","DOI":"10.1248\/jhs.49.444"},{"key":"bibr25-2156587217718979","doi-asserted-by":"publisher","DOI":"10.3923\/ajb.2007.224.236"},{"key":"bibr26-2156587217718979","first-page":"4","volume":"5","author":"Oluwole OB","year":"2015","journal-title":"J Nutr Disorders Ther"},{"key":"bibr27-2156587217718979","first-page":"868937","author":"Erukainure OL","year":"2015","journal-title":"Biochem Res Int"},{"key":"bibr28-2156587217718979","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2006.09.017"},{"key":"bibr29-2156587217718979","first-page":"2223","volume":"59","author":"Johnston DE","year":"1999","journal-title":"Am Fam Physician"},{"key":"bibr30-2156587217718979","doi-asserted-by":"publisher","DOI":"10.1007\/s12098-007-0118-7"},{"key":"bibr31-2156587217718979","first-page":"308","volume":"18","author":"Saidu Y","year":"2010","journal-title":"Nigerian J Basic Appl Sci"},{"key":"bibr32-2156587217718979","first-page":"170","volume":"2","author":"Gowda S","year":"2010","journal-title":"N Am J Med Sci"},{"key":"bibr33-2156587217718979","doi-asserted-by":"publisher","DOI":"10.1016\/S1995-7645(10)60024-7"},{"key":"bibr34-2156587217718979","first-page":"15","volume":"11","author":"Ayoola PB","year":"2011","journal-title":"J Pharm Biomed Sci"},{"key":"bibr35-2156587217718979","doi-asserted-by":"publisher","DOI":"10.1177\/2156587216636505"}],"container-title":["Journal of Evidence-Based Complementary &amp; Alternative Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2156587217718979","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2156587217718979","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2156587217718979","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T15:09:32Z","timestamp":1777388972000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/2156587217718979"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,18]]},"references-count":35,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["10.1177\/2156587217718979"],"URL":"https:\/\/doi.org\/10.1177\/2156587217718979","relation":{},"ISSN":["2156-5872","2156-5899"],"issn-type":[{"value":"2156-5872","type":"print"},{"value":"2156-5899","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,18]]}}}