{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T18:24:00Z","timestamp":1789928640160,"version":"4.0.1"},"reference-count":36,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Evid Based Complementary Altern Med"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:p>\n                    Extracts of Desmodium adscendens (Sw) DC are used for the treatment of various diseases but limited toxicological evaluations have been done on the medicinal plant. This study investigates toxicity effects of the leave extract of D adscendens, and the possibility of drug-drug interaction of the plant extract when co-administered with other drugs. Oral administrations of leaf extract of D adscendens to white Wistar rats in an acute toxicity studies allowed the estimation of an LD\n                    <jats:sub>50<\/jats:sub>\n                    (median lethal dose) value of 1122 mg\/kg body weight. In a subchronic toxicity studies, the plant extract caused a decrease in zoxazolamine paralysis time and prevented thiopentone from causing sleep in test animals compared to controls. Overall, the results are consistent with the plant extract being safe at the doses administered in humans. However, the induction of the CYP enzymes is an indication of a possible drug interaction when the plant extract is co-administered with other drugs.\n                  <\/jats:p>","DOI":"10.1177\/2156587217736587","type":"journal-article","created":{"date-parts":[[2017,11,7]],"date-time":"2017-11-07T06:48:36Z","timestamp":1510037316000},"page":"753-759","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Acute and Subchronic Toxicity Studies of Aqueous Extract of\n                    <i>Desmodium adscendens<\/i>\n                    (Sw) DC"],"prefix":"10.1177","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0621-876X","authenticated-orcid":false,"given":"Osbourne","family":"Quaye","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Cell & Molecular Biology, University of Ghana, Legon, Accra, Ghana"},{"name":"West African Center for Cell Biology of Infectious Pathogens (WACCBIP), University of Ghana, Legon, Accra, Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Precious","family":"Cramer","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Cell & Molecular Biology, University of Ghana, Legon, Accra, Ghana"},{"name":"West African Center for Cell Biology of Infectious Pathogens (WACCBIP), University of Ghana, Legon, Accra, Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Ofosuhene","sequence":"additional","affiliation":[{"name":"Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Accra, Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laud K. 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