{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T14:08:25Z","timestamp":1784038105759,"version":"3.55.0"},"reference-count":65,"publisher":"SAGE Publications","issue":"4-5","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100002661","name":"Fonds De La Recherche Scientifique - FNRS","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002661","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Brain Connectivity"],"published-print":{"date-parts":[[2026,6,1]]},"abstract":"<jats:sec>\n                    <jats:title>\n                      <jats:italic toggle=\"yes\">Background:<\/jats:italic>\n                    <\/jats:title>\n                    <jats:p>Tinnitus is an auditory phantom perception in the absence of any corresponding acoustic stimulus whose pathophysiology remains poorly understood. This study aimed to investigate alterations in the functional organization of the brain in individuals with tinnitus using resting-state functional magnetic resonance imaging (rs-fMRI) and graph theory analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>\n                      <jats:italic toggle=\"yes\">Methods:<\/jats:italic>\n                    <\/jats:title>\n                    <jats:p>We conducted a study including 44 individuals with tinnitus and 32 healthy controls. Using rs-fMRI and graph theory measures, we characterized whole-brain topological properties, including network segregation, integration, small-worldness, and global efficiency. In addition, regional segregation and integration were assessed using clustering coefficient and participation coefficient analyses to identify alterations in brain hub regions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>\n                      <jats:italic toggle=\"yes\">Results:<\/jats:italic>\n                    <\/jats:title>\n                    <jats:p>Our findings revealed altered topological properties in the tinnitus brain, particularly in the balance between cerebral segregation and integration, leading to deviations from optimal small-world architecture. We also observed alterations in the topology of specific auditory and nonauditory brain regions associated with phantom sound perception. Notably, patients with tinnitus exhibited a decreased nodal participation coefficient in the thalamus, suggesting reduced connectivity between this region and different functional modules as well as long-range connections.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>\n                      <jats:italic toggle=\"yes\">Conclusions:<\/jats:italic>\n                    <\/jats:title>\n                    <jats:p>These results suggest that tinnitus is associated with alterations in the functional organization of the brain, leading to disrupted information processing and sensory integration.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/21580014261455378","type":"journal-article","created":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T08:01:36Z","timestamp":1781164896000},"page":"180-192","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Tinnitus Brain: A Functional Reorganization?"],"prefix":"10.1177","volume":"16","author":[{"given":"Marie","family":"Detroz","sequence":"first","affiliation":[{"name":"Sensation and Perception Research Group, GIGA Consciousness, University of Li\u00e8ge, Li\u00e8ge, Belgium."},{"name":"Otorhinolaryngology Head and Neck Surgery Department, University Hospital of Li\u00e8ge, Li\u00e8ge, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajanikant","family":"Panda","sequence":"additional","affiliation":[{"name":"Sensation and Perception Research Group, GIGA Consciousness, University of Li\u00e8ge, Li\u00e8ge, Belgium."},{"name":"Coma Science Group, GIGA-Consciousness, University of Li\u00e8ge, Li\u00e8ge, Belgium."},{"name":"Centre du Cerveau2, University Hospital of Li\u00e8ge, Li\u00e8ge, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey","family":"Vanhaudenhuyse","sequence":"additional","affiliation":[{"name":"Sensation and Perception Research Group, GIGA Consciousness, University of Li\u00e8ge, Li\u00e8ge, Belgium."},{"name":"Interdisciplinary Algology Center, CHU of Li\u00e8ge, Li\u00e8ge, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luaba","family":"Tshibanda","sequence":"additional","affiliation":[{"name":"Radiology Department, University Hospital of Li\u00e8ge, Li\u00e8ge, Li\u00e8ge, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3096-3807","authenticated-orcid":false,"given":"Steven","family":"Laureys","sequence":"additional","affiliation":[{"name":"Coma Science Group, GIGA-Consciousness, University of Li\u00e8ge, Li\u00e8ge, Belgium."},{"name":"Centre du Cerveau2, University Hospital of Li\u00e8ge, Li\u00e8ge, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Lefebvre","sequence":"additional","affiliation":[{"name":"Sensation and Perception Research Group, GIGA Consciousness, University of Li\u00e8ge, Li\u00e8ge, Belgium."},{"name":"Otorhinolaryngology Head and Neck Surgery Department, University Hospital of Li\u00e8ge, Li\u00e8ge, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey","family":"Maudoux","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Head and Neck Surgery Department, University Hospital of Li\u00e8ge, Li\u00e8ge, Belgium."},{"name":"Universit\u00e9 Paris Cit\u00e9, INSERM AO06, Institut de l\u2019Audition, ReConnect institute, Unit Progressive Sensory Disorders, Pathophysiology and Therapy, Institut Pasteur, Paris, France."},{"name":"Pediatric Otorhinolaryngology Department, Assistance Publique des H\u00f4pitaux de Paris, University Robert-Debr\u00e9 Hospital, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,6,11]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.0030017"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-07173-9"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2017.10.029"},{"key":"e_1_3_3_5_1","unstructured":"Baars B. 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