{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:18:01Z","timestamp":1787163481216,"version":"build-2736575974"},"reference-count":82,"publisher":"SAGE Publications","issue":"4-5","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Surgeon General\u2019s Health Research Program of the Canadian National Defence and Veterans Affairs Canada"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Brain Connectivity"],"published-print":{"date-parts":[[2026,6,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Investigation of the neural substrates of post-traumatic stress disorder (PTSD) in military personnel using whole-brain approaches remains scarce, hindering the development of circuit-based neuromodulatory interventions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>This study aimed to identify potential associations between clinical symptoms and whole-brain resting-state functional connectivity with magnetic resonance imaging in military personnel with adulthood-onset war-related PTSD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Thirty-seven soldiers from the Canadian Armed Forces with moderate to severe treatment-resistant PTSD participated in this study. We assessed PTSD, anxiety and depressive symptoms, quality of life, and time since trauma. We characterized the whole-brain functional connectome using independent component analysis and regions of interest (ROI)-to-ROI connectivity, as well as its topology using graph theory.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Greater severity of PTSD and anxiety symptoms was associated with lower connectivity (\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      &lt; 0) between the default mode network (DMN) and frontoparietal network. Greater severity of PTSD symptoms was also associated with a higher nodal clustering coefficient of the inferior parietal lobule from the DMN. Greater severity of anxiety symptoms and longer time since trauma was the only clinical variables that correlated with higher connectivity patterns, all involving the visual networks (the frontoparietal-visual, the visual-DMN, and within-visual networks).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>This work contributes to identifying brain targets for the development of personalized neuromodulatory interventions. In particular, the DMN may be a promising target to alleviate PTSD symptoms, and the visual network may be a target to treat comorbid anxiety symptoms.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/21580014261456366","type":"journal-article","created":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T08:02:15Z","timestamp":1781337735000},"page":"193-203","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Clinical Correlates of Resting-State Functional Magnetic Resonance Imaging in Military Personnel with Adulthood\u2014Onset War\u2014Related Post\u2014Traumatic Stress Disorder"],"prefix":"10.1177","volume":"16","author":[{"given":"Olivier","family":"Roy","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Neurosciences, Universit\u00e9 Laval, Quebec, Canada."},{"name":"CERVO Brain Research Centre, Quebec, Canada."},{"name":"Centre int\u00e9gr\u00e9 universitaire de sant\u00e9 et de services sociaux de la Capitale-Nationale, Quebec, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Levasseur-Moreau","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurosciences, Universit\u00e9 Laval, Quebec, Canada."},{"name":"CERVO Brain Research Centre, Quebec, Canada."},{"name":"Centre int\u00e9gr\u00e9 universitaire de sant\u00e9 et de services sociaux de la Capitale-Nationale, Quebec, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuelle","family":"Renauld","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurosciences, Universit\u00e9 Laval, Quebec, Canada."},{"name":"CERVO Brain Research Centre, Quebec, Canada."},{"name":"Centre int\u00e9gr\u00e9 universitaire de sant\u00e9 et de services sociaux de la Capitale-Nationale, Quebec, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marine","family":"Mondino","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurosciences, Universit\u00e9 Laval, Quebec, Canada."},{"name":"CERVO Brain Research Centre, Quebec, Canada."},{"name":"Centre int\u00e9gr\u00e9 universitaire de sant\u00e9 et de services sociaux de la Capitale-Nationale, Quebec, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc J.","family":"H\u00e9bert","sequence":"additional","affiliation":[{"name":"Centre int\u00e9gr\u00e9 universitaire de sant\u00e9 et de services sociaux de la Capitale-Nationale, Quebec, Canada."},{"name":"Centre Interdisciplinaire de Recherche en R\u00e9adaptation et Int\u00e9gration Sociale, Quebec, Canada."},{"name":"School of Rehabilitation Sciences and Department of Radiology and Nuclear Medicine, Universit\u00e9 Laval, Quebec, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Martin","family":"Beaulieu","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurosciences, Universit\u00e9 Laval, Quebec, Canada."},{"name":"CERVO Brain Research Centre, Quebec, Canada."},{"name":"Centre int\u00e9gr\u00e9 universitaire de sant\u00e9 et de services sociaux de la Capitale-Nationale, Quebec, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathieu","family":"Bilodeau","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurosciences, Universit\u00e9 Laval, Quebec, Canada."},{"name":"CERVO Brain Research Centre, Quebec, Canada."},{"name":"Centre int\u00e9gr\u00e9 universitaire de sant\u00e9 et de services sociaux de la Capitale-Nationale, Quebec, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9781-4451","authenticated-orcid":false,"given":"Shirley","family":"Fecteau","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurosciences, Universit\u00e9 Laval, Quebec, Canada."},{"name":"CERVO Brain Research Centre, Quebec, Canada."},{"name":"Centre int\u00e9gr\u00e9 universitaire de sant\u00e9 et de services sociaux de la Capitale-Nationale, Quebec, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,6,13]]},"reference":[{"key":"e_1_3_4_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2017.04.046"},{"key":"e_1_3_4_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.0030017"},{"key":"e_1_3_4_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11920-017-0840-4"},{"key":"e_1_3_4_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2018.05.005"},{"key":"e_1_3_4_6_1","volume-title":"Diagnostic and Statistical Manual of Mental Disorders: DSM-IV-TR, 4th ed., text revision","author":"American Psychiatric Association","year":"2000","unstructured":"American Psychiatric Association. 2000. 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