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We recruited individuals aged 18\u201325 (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u2009314) who were homeless and unstably housed (e.g., living in the streets with friends, hotels, or shelters). We measured COVID-19 fear and impact quantitatively and analyzed it using descriptive statistics. Concurrently, we conducted in-person or phone interviews to examine the experiences of YEH (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u200940). Thematic analysis was used to organize the findings. YEH identifying as LGBTQ+ youth within this community confronted exacerbated challenges. LGBTQ+ youth had significantly higher fear and impact scores when compared to non- LGBTQ+ youth (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u2009.02). Qualitative narratives illuminated the profound impact of the COVID-19 pandemic, revealing systemic inequities that disproportionately affected LGBTQ+. Distinct vulnerabilities emerged, encompassing economic strains, restricted healthcare access, and intensified social disconnections. Findings underscores the intricate layers of vulnerability within YEH populations during global health crises. The research accentuates the urgent need for systemic reforms and targeted interventions by integrating insights from a Social Determinants of Health framework. The findings offer invaluable knowledge for policymakers, service providers, and stakeholders, advocating for strategies that address disparities and promote equitable health outcomes among YEH.\n                  <\/jats:p>","DOI":"10.1177\/21582440261442626","type":"journal-article","created":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T08:39:55Z","timestamp":1776501595000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["COVID-19 Impact on the Lives of Youth Experiencing Homelessness: A Concurrent Mixed Methods Study"],"prefix":"10.1177","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4992-7096","authenticated-orcid":false,"given":"Higinio","family":"Fernandez-Sanchez","sequence":"first","affiliation":[{"name":"University of Texas Health Science Center at Houston, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5293-9755","authenticated-orcid":false,"given":"Marguerita","family":"Lightfoot","sequence":"additional","affiliation":[{"name":"Oregon Health and Science University, Portland State University School of Public Health, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4979-6620","authenticated-orcid":false,"given":"Adeline","family":"Nyamathi","sequence":"additional","affiliation":[{"name":"University of California Irvine, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary","family":"Paul","sequence":"additional","affiliation":[{"name":"Baylor College of Medicine, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasmeen","family":"Quadri","sequence":"additional","affiliation":[{"name":"Baylor College of Medicine, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5738-7486","authenticated-orcid":false,"given":"Nikhil","family":"Padhye","sequence":"additional","affiliation":[{"name":"University of Texas Health Science Center at Houston, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9210-010X","authenticated-orcid":false,"given":"Jennifer","family":"Jones","sequence":"additional","affiliation":[{"name":"University of Texas Health Science Center at Houston, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huining","family":"Sun","sequence":"additional","affiliation":[{"name":"University of Texas Health Science Center at Houston, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diane","family":"Santa Maria","sequence":"additional","affiliation":[{"name":"University of Texas Health Science Center at Houston, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,4,18]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"crossref","unstructured":"Abramovich A. 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