{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T07:20:31Z","timestamp":1777879231084,"version":"3.51.4"},"reference-count":17,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.liebertpub.com\/nv\/resources-tools\/text-and-data-mining-policy\/121\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nucleic Acid Therapeutics"],"published-print":{"date-parts":[[2025,12,1]]},"DOI":"10.1177\/21593337251375804","type":"journal-article","created":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T04:00:02Z","timestamp":1757908802000},"page":"298-303","source":"Crossref","is-referenced-by-count":0,"title":["Use of a Transgenic Human PNPLA3\n                    <sup>I148M<\/sup>\n                    Knock-in Mouse for Translational Safety Evaluations of siRNA Therapeutics"],"prefix":"10.1177","volume":"35","author":[{"given":"Ben","family":"Brooks","sequence":"first","affiliation":[{"name":"Translational Safety & Risk Sciences, Amgen, Inc, Thousand Oaks, California, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Artem","family":"Shkumatov","sequence":"additional","affiliation":[{"name":"Translational Safety & Risk Sciences, Amgen, Inc, South San Francisco, California, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jackson","family":"Kalanzi","sequence":"additional","affiliation":[{"name":"Translational Safety & Risk Sciences, Amgen, Inc, Thousand Oaks, California, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kim","family":"Henderson Park","sequence":"additional","affiliation":[{"name":"Translational Safety & Risk Sciences, Amgen, Inc, Thousand Oaks, California, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie M.","family":"Lade","sequence":"additional","affiliation":[{"name":"Pharmacokinetics & Drug Metabolism, Amgen, Inc., South San Francisco, California, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana","family":"Wong","sequence":"additional","affiliation":[{"name":"Pharmacokinetics & Drug Metabolism, Amgen, Inc., South San Francisco, California, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Dou","sequence":"additional","affiliation":[{"name":"Lead Discovery & Characterization, Amgen, Inc., South San Francisco, California, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason","family":"Long","sequence":"additional","affiliation":[{"name":"Genetic Medicine, Therapeutic Discovery, Amgen, Inc., Thousand Oaks, California, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3251-3989","authenticated-orcid":false,"given":"Ingrid C.","family":"Rulifson","sequence":"additional","affiliation":[{"name":"Cardiometabolic Disorders, Amgen, South San Francisco, California, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin K.","family":"Murray","sequence":"additional","affiliation":[{"name":"Genetic Medicine, Therapeutic Discovery, Amgen, Inc., Thousand Oaks, California, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren","family":"Mihalcik","sequence":"additional","affiliation":[{"name":"Translational Safety & Risk Sciences, Amgen, Inc, Thousand Oaks, California, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2734-9363","authenticated-orcid":false,"suffix":"Jr","given":"Tod A.","family":"Harper","sequence":"additional","affiliation":[{"name":"Translational Safety & Risk Sciences, Amgen, Inc, Thousand Oaks, California, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.257"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2023.04.024"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1186\/s12902-021-00789-4"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcmed.2024.103043"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-019-1364-z"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2025.01.019"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1101\/2024.10.29.620978"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2024.10.048"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1089\/nat.2021.0026"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.14573\/altex.2108241"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2025.104328"},{"key":"B12","volume-title":"M3 (R2): Guidance on nonclinical safety studies for the conduct of human clinical trials and marketing authorization for pharmaceuticals","author":"ICH Harmonized Tripartite Guideline","year":"2009"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27242"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1093\/advances\/nmy002"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2019.01.013"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1111\/liv.15587"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1177\/0192623318792537"}],"container-title":["Nucleic Acid Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.liebertpub.com\/doi\/full-xml\/10.1177\/21593337251375804","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.liebertpub.com\/doi\/pdf\/10.1177\/21593337251375804","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T23:38:24Z","timestamp":1777592304000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.1177\/21593337251375804"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,1]]},"references-count":17,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,12,1]]}},"alternative-id":["10.1177\/21593337251375804"],"URL":"https:\/\/doi.org\/10.1177\/21593337251375804","relation":{},"ISSN":["2159-3337","2159-3345"],"issn-type":[{"value":"2159-3337","type":"print"},{"value":"2159-3345","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,1]]}}}