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They are generated through an\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    selection process known as Systematic Evolution of Ligands by Exponential Enrichment. Aptamers show significant promise in cancer diagnostics and therapeutics due to their specificity, versatility, and tunable biochemical properties. Aptamers can be used to target cellular biomarkers, which are detectable molecules that can indicate specific physiological states of cells, organs, and organisms, making them valuable indicators for diseases. Clinical trials on therapeutic aptamers are providing further insight into their potential use. Leukemia is a hematological malignancy characterized by the uncontrolled proliferation of abnormal blood-forming cells, primarily affecting the bone marrow and peripheral blood. This review will highlight the applications of aptamers in relation to the diagnosis and treatment of leukemia. Novel research on leukemia-related aptamers will be presented along with future directions for aptamer-based diagnostic and therapeutic methods.\n                  <\/jats:p>","DOI":"10.1177\/21593337261458148","type":"journal-article","created":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T06:50:58Z","timestamp":1781592658000},"page":"187-201","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Aptamers: Current Applications in Leukemia Diagnostics and Therapeutics"],"prefix":"10.1177","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-8294-8074","authenticated-orcid":false,"given":"Bahareh","family":"Hosseinpour","sequence":"first","affiliation":[{"name":"Department of Chemistry, Faculty of Science, Carleton University, Ottawa, Ontario, Canada."},{"name":"Terasaki Institute, Los Angeles, California, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0719-4460","authenticated-orcid":false,"given":"Joshua","family":"O\u2019Grady","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science, Carleton University, Ottawa, Ontario, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2796-4315","authenticated-orcid":false,"given":"Neda","family":"Mohaghegh","sequence":"additional","affiliation":[{"name":"Terasaki Institute, Los Angeles, California, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Hamati","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science, Carleton University, Ottawa, Ontario, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7408-4057","authenticated-orcid":false,"given":"Erin M.","family":"McConnell","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science, Carleton University, Ottawa, Ontario, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3874-7954","authenticated-orcid":false,"given":"William G.","family":"Willmore","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science, Carleton University, Ottawa, Ontario, Canada."},{"name":"Institute of Biochemistry, Faculty of Science, Carleton University, Ottawa, Ontario, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8215-4374","authenticated-orcid":false,"given":"Alireza","family":"Hassani Najafabadi","sequence":"additional","affiliation":[{"name":"Terasaki Institute, Los Angeles, California, USA."},{"name":"College of Pharmacy, University of Cincinnati, Ohio, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1868-6357","authenticated-orcid":false,"given":"Maria C.","family":"DeRosa","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science, Carleton University, Ottawa, Ontario, Canada."},{"name":"Institute of Biochemistry, Faculty of Science, Carleton University, Ottawa, Ontario, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,6,15]]},"reference":[{"key":"e_1_3_2_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2014.10.043"},{"key":"e_1_3_2_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)33018-1"},{"key":"e_1_3_2_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph9082875"},{"key":"e_1_3_2_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cma.2010.02.010"},{"key":"e_1_3_2_6_1","doi-asserted-by":"publisher","DOI":"10.1039\/c8bm01393d"},{"key":"e_1_3_2_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-12-4938"},{"key":"e_1_3_2_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/46.8.1221"},{"key":"e_1_3_2_9_1","first-page":"7","article-title":"Canadian trends in cancer prevalence","volume":"23","author":"Ellison LF","year":"2012","unstructured":"8.Ellison LF, , Wilkins K. 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