{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T19:40:51Z","timestamp":1790192451290,"version":"4.1.0"},"reference-count":22,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:00:00Z","timestamp":1768780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"NIH\/NCI","award":["NIH\/NCI Cancer Center Support Grant P30 CA008748"],"award-info":[{"award-number":["NIH\/NCI Cancer Center Support Grant P30 CA008748"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Advances in Wound Care"],"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Evaluate quality of life (QoL) of patients with malignant wounds at baseline and through the course of management at a dedicated malignant wound care clinic.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Retrospective review of patients with malignant wounds seen at a dedicated wound care clinic between January 2016 and April 2023 who completed the Skindex-16, a validated dermatologic QoL questionnaire. Clinical symptoms and management data were extracted from electronic medical records.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      At baseline, patients reported high Skindex-16 scores across symptoms (mean = 64.2, standard deviation [SD] = 33.3), emotions (mean = 44.8, SD = 31.2), and functioning (mean = 67.7, SD = 29.7) domains. Overall Skindex-16 scores significantly improved over time, with a mean reduction of 4.9 points per visit (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.002). Multimodal symptom management, including both topical and systemic treatments, and modern dressings were commonly utilized.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Implications:<\/jats:title>\n                    <jats:p>Early referral to specialized wound care allows timely initiation of symptom-directed interventions to reduce pain, bleeding, odor, and infection risk. QoL improvements are often seen after the first follow-up visit, with the greatest benefit between the first and second visits. Access to structured wound care not only alleviates symptom burden but also supports continuation of oncologic treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Innovation:<\/jats:title>\n                    <jats:p>This study is the first to longitudinally assess malignant wound-related quality using a dermatology-specific instrument, the Skindex-16, in a real-world clinical setting. These findings highlight a model for integrating dermatologic wound care into supportive oncology and demonstrate that malignant wounds, often regarded as irreversible, can be meaningfully palliated with dedicated care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Dedicated wound care was associated with statistically significant improvements in QoL for patients with malignant wounds. Early referral to specialized wound clinics may enhance palliative care for these patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/21621918251393741","type":"journal-article","created":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T15:00:32Z","timestamp":1762786832000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Improving Quality of Life in Patients with Malignant Wounds: Outcomes from a Specialized Wound Care Clinic"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9620-8276","authenticated-orcid":false,"given":"Ian","family":"Nykaza","sequence":"first","affiliation":[{"name":"Department of Medicine, Dermatology Service, Memorial Sloan Kettering Cancer Center, New York, New York, USA."},{"name":"Weill Cornell Medicine, New York, New York, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Medicine, Dermatology Service, Memorial Sloan Kettering Cancer Center, New York, New York, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Dusza","sequence":"additional","affiliation":[{"name":"Department of Medicine, Dermatology Service, Memorial Sloan Kettering Cancer Center, New York, New York, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline","family":"Bromberg","sequence":"additional","affiliation":[{"name":"Department of Medicine, Breast Cancer Service, Memorial Sloan Kettering Cancer Center, New York, New York, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cara","family":"Norelli","sequence":"additional","affiliation":[{"name":"Department of Medicine, Dermatology Service, Memorial Sloan Kettering Cancer Center, New York, New York, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shari","family":"Goldfarb","sequence":"additional","affiliation":[{"name":"Department of Medicine, Breast Cancer Service, Memorial Sloan Kettering Cancer Center, New York, New York, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Sanford","sequence":"additional","affiliation":[{"name":"Department of Medicine, Breast Cancer Service, Memorial Sloan Kettering Cancer Center, New York, New York, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alina","family":"Markova","sequence":"additional","affiliation":[{"name":"Department of Medicine, Dermatology Service, Memorial Sloan Kettering Cancer Center, New York, New York, USA."},{"name":"Weill Cornell Medicine, New York, New York, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,1,19]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2024.33.2.102"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejon.2009.03.008"},{"issue":"6","key":"e_1_3_4_4_2","first-page":"214","article-title":"Evidence corner: Evidence-based care for malignant wounds","volume":"28","author":"Bolton L","year":"2016","unstructured":"Bolton L. Evidence corner: Evidence-based care for malignant wounds. Wounds Compend Clin Res Pract, 2016; 28(6):214\u2013216.","journal-title":"Wounds Compend Clin Res Pract"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-022-07194-0"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2008.01.009"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2025.02.021"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mds103"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2017.26.Sup1.S4"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2023.32.2.122"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2020.29.Sup9b.S1"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2024.33.4.262"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1177\/120347540100500202"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2011.11.003"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2020.04.024"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1684\/ejd.2018.3448"},{"issue":"3","key":"e_1_3_4_17_2","first-page":"192","article-title":"Validation of the Skindex-16 questionnaire for assessing patient-reported outcomes in radiation dermatitis among breast cancer patients","volume":"33","author":"Day M","year":"2025","unstructured":"Day M, , Kuszaj O, , Zhang L, et al. Validation of the Skindex-16 questionnaire for assessing patient-reported outcomes in radiation dermatitis among breast cancer patients. Support Care Cancer, 2025; 33(3):192.","journal-title":"Support Care Cancer"},{"issue":"5","key":"e_1_3_4_18_2","first-page":"1151","article-title":"Evaluation of Skindex-16 construct validity in routinely collected psoriasis data: A retrospective analysis of the relationship between overall physician global assessment scores and Skindex-16 and measure discordance","volume":"315","author":"Hopkins ZH","year":"2023","unstructured":"Hopkins ZH, , Kuceki G, , Taliercio VL, et al. Evaluation of Skindex-16 construct validity in routinely collected psoriasis data: A retrospective analysis of the relationship between overall physician global assessment scores and Skindex-16 and measure discordance. 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