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This frequently results in chronic wounds that compromise patient outcomes and quality of life.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Recent Advances:<\/jats:title>\n                    <jats:p>Improved understanding of the pathophysiology behind radiation-induced soft tissue injury has led to the development of promising treatments. These include dermal substitutes, placental derivatives, fibronectin, injectable fat-derived and plasma-derived compounds, hyperbaric oxygen, and deferoxamine.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Critical Issues:<\/jats:title>\n                    <jats:p>Many traditional approaches to wound healing are often limited by poor tissue quality seen following XRT. A better understanding of mechanisms by which radiation induces these pathological changes may lead to the development of more effective therapeutics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Future Directions:<\/jats:title>\n                    <jats:p>Treatments leveraging recent insights into collateral radiation injury may help to condition tissue to promote healing\/regeneration of wounds. Although animal studies and human case reports have been promising, wide-scale clinical studies examining their efficacy are still needed before many of these novel strategies may be adopted to help the millions of patients worldwide suffering from radiation-related cutaneous wounds.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/21621918251400347","type":"journal-article","created":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T05:15:12Z","timestamp":1764220512000},"page":"613-638","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["The Challenge of Healing Wounds in Radiation-Injured Skin"],"prefix":"10.1177","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6770-5561","authenticated-orcid":false,"given":"Christopher V.","family":"Lavin","sequence":"first","affiliation":[{"name":"Hagey Laboratory for Pediatric Regenerative Medicine, Stanford University School of Medicine, 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