{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T05:17:10Z","timestamp":1783142230949,"version":"3.54.6"},"reference-count":38,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T00:00:00Z","timestamp":1766361600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Advances in Wound Care"],"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>\n                      Burn injuries affect over 11 million people annually, and methicillin-resistant\n                      <jats:italic toggle=\"yes\">Staphylococcus aureus<\/jats:italic>\n                      (MRSA) infection significantly delays healing by sustaining inflammation and promoting scarring. This study evaluated\n                      <jats:italic toggle=\"yes\">N<\/jats:italic>\n                      -benzyl benzenamine 4k\u2014a novel dual-action compound with antibacterial and anti-inflammatory properties\u2014in a murine model of MRSA-infected burn wounds.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Approach:<\/jats:title>\n                    <jats:p>\n                      Skin safety of 4k was assessed through acute toxicity, sensitization, and irritation tests in BALB\/c mice. A full-thickness burn model infected with MRSA2858 (1 \u00d7 10\n                      <jats:sup>8<\/jats:sup>\n                      CFU\/mL) was treated topically with 4k, vancomycin (VAN), or vaseline. Outcomes included wound closure, bacterial load, histology, collagen organization, macrophage polarization markers (CD86\/inducible nitric oxide synthase [iNOS] for M1; CD206\/vascular endothelial growth factor [VEGF] for M2), cytokine levels, and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-\u03baB) pathway proteins.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>4k demonstrated excellent dermal tolerability with no toxicity or irritation. Topical 4k reduced MRSA colonization and accelerated wound closure (residual wound area at day 15: 4k = 8.4 \u00b1 2.2%, VAN = 17.8 \u00b1 3.5%). Histology revealed organized collagen deposition and minimal scarring in the 4k group (scar score: 2.33 \u00b1 0.58 vs. 13.33 \u00b1 0.58 for vaseline). Mechanistically, 4k suppressed NF-\u03baB activation, downregulated M1 markers (CD86, iNOS, tumor necrosis factor-alpha, and interleukin [IL]-6), and upregulated M2 markers (CD206, VEGF, transforming growth factor-beta 1, and IL-10), promoting a prohealing immune environment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Innovation:<\/jats:title>\n                    <jats:p>This study introduces a dual-action topical therapy that combines potent antibacterial activity with immunomodulation, offering a promising strategy to overcome antibiotic resistance and improve burn wound outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>\n                      <jats:italic toggle=\"yes\">N<\/jats:italic>\n                      -benzyl benzenamine 4k effectively eradicates MRSA, accelerates wound healing, and minimizes scarring through NF-\u03baB inhibition and macrophage polarization, supporting its potential as a next-generation burn care agent.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/21621918251405876","type":"journal-article","created":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T07:33:10Z","timestamp":1766734390000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Dual-Action Topical Therapy Accelerates Healing of MRSA-Infected Burn Wounds by Targeting Infection and Inflammation"],"prefix":"10.1177","author":[{"given":"Miaoqing","family":"Xiang","sequence":"first","affiliation":[{"name":"School of Medicine, Anhui University of Science and Technology, Huainan, China."},{"name":"Anhui Province Key Laboratory of Occupational Health, Anhui No. 2 Provincial People\u2019s Hospital, Hefei, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongze","family":"Yao","sequence":"additional","affiliation":[{"name":"School of Medicine, Anhui University of Science and Technology, Huainan, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Shao","sequence":"additional","affiliation":[{"name":"Joint Research Center for Occupational Medicine and Health of IHM, Anhui University of Science and Technology, Huainan, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengru","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Medicine, Anhui University of Science and Technology, Huainan, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjian","family":"Tang","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Anhui Medical University, Hefei, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dandan","family":"Liu","sequence":"additional","affiliation":[{"name":"Anhui Province Key Laboratory of Occupational Health, Anhui No. 2 Provincial People\u2019s Hospital, Hefei, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6160-9026","authenticated-orcid":false,"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Anhui Province Key Laboratory of Occupational Health, Anhui No. 2 Provincial People\u2019s Hospital, Hefei, China."},{"name":"Joint Research Center for Occupational Medicine and Health of IHM, Anhui University of Science and Technology, Huainan, 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