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In the current study we examined whether negatively biased self-referential processing, negative life events, baseline depressive symptoms, and psychotropic medication use predicted the onset of a subsequent depressive episode in a longitudinal study of women with a history of recurrent MDD. Higher levels of depressive symptoms at baseline predicted experiencing a greater number of negative life events, which, in turn, tended to predict recurrence of depression. It is important that after accounting for other associations, negatively biased self-referential processing contributed unique variance to the likelihood of experiencing a depressive episode over the next 3 years. Thus, negatively biased self-referential processing appears to be a significant risk factor for the recurrence of depressive episodes and may be an important target for interventions aimed at preventing future episodes.<\/jats:p>","DOI":"10.1177\/2167702616654898","type":"journal-article","created":{"date-parts":[[2016,10,19]],"date-time":"2016-10-19T23:44:08Z","timestamp":1476920648000},"page":"174-181","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":101,"title":["Negative Self-Referential Processing Predicts the Recurrence of Major Depressive Episodes"],"prefix":"10.1177","volume":"5","author":[{"given":"Joelle","family":"LeMoult","sequence":"first","affiliation":[{"name":"Stanford University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Kircanski","sequence":"additional","affiliation":[{"name":"Stanford University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gautam","family":"Prasad","sequence":"additional","affiliation":[{"name":"University of Southern California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian H.","family":"Gotlib","sequence":"additional","affiliation":[{"name":"Stanford University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,10,20]]},"reference":[{"key":"bibr1-2167702616654898","doi-asserted-by":"publisher","DOI":"10.1037\/0021-843X.115.1.145"},{"key":"bibr2-2167702616654898","volume-title":"Diagnostic and statistical manual of mental disorders","author":"American Psychiatric Association","year":"2000","edition":"4"},{"key":"bibr3-2167702616654898","unstructured":"Asparouhov T., Muth\u00e9n B. 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