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In addition, little is known about the neural processes underlying this abnormality among those high in PS. Finally, no studies have tested whether startle potentiation and limbic neural reactivity\u2014commonly used indices of U-threat responsivity\u2014are associated and therefore reflect common abnormalities. These questions were investigated in 42 adults with a range of PS. U-threat responding was measured twice during threat of shock\u2014once with startle and once with functional magnetic resonance imaging. As hypothesized, PS positively predicted startle potentiation and dACC reactivity to U-threat. Startle potentiation and dACC activation to U-threat were positively associated. These results suggest a biobehavioral profile of aberrant responding to U-threat associated with PS.<\/jats:p>","DOI":"10.1177\/2167702616666507","type":"journal-article","created":{"date-parts":[[2016,10,22]],"date-time":"2016-10-22T00:14:55Z","timestamp":1477095295000},"page":"52-63","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":25,"title":["Impact of Panic on Psychophysiological and Neural Reactivity to Unpredictable Threat in Depression and Anxiety"],"prefix":"10.1177","volume":"5","author":[{"given":"Lynne","family":"Lieberman","sequence":"first","affiliation":[{"name":"Department of Psychology, University of Illinois-Chicago"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie M.","family":"Gorka","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Illinois-Chicago"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stewart A.","family":"Shankman","sequence":"additional","affiliation":[{"name":"Department of Psychology, University of Illinois-Chicago"},{"name":"Department of Psychiatry, University of Illinois-Chicago"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. 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