{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T13:16:11Z","timestamp":1789996571667,"version":"4.0.1"},"reference-count":56,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T00:00:00Z","timestamp":1659052800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R21MH112770"],"award-info":[{"award-number":["R21MH112770"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007921","name":"university of pittsburgh","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007921","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clinical Psychological Science"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:p>Compulsive behaviors (CBs) have been linked to orbitofrontal cortex (OFC) function in animal and human studies. However, brain regions function not in isolation but as components of widely distributed brain networks\u2014such as those indexed via resting-state functional connectivity (RSFC). Sixty-nine individuals with CB disorders were randomized to receive a single session of neuromodulation targeting the left OFC\u2014intermittent theta-burst stimulation (iTBS) or continuous TBS (cTBS)\u2014followed immediately by computer-based behavioral \u201chabit override\u201d training. OFC seeds were used to quantify RSFC following iTBS and following cTBS. Relative to cTBS, iTBS showed increased RSFC between right OFC (Brodmann\u2019s area 47) and other areas, including dorsomedial prefrontal cortex (dmPFC), occipital cortex, and a priori dorsal and ventral striatal regions. RSFC connectivity effects were correlated with OFC\/frontopolar target engagement and with subjective difficulty during habit-override training. Findings help reveal neural network-level impacts of neuromodulation paired with a specific behavioral context, informing mechanistic intervention development.<\/jats:p>","DOI":"10.1177\/21677026221103136","type":"journal-article","created":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T14:06:48Z","timestamp":1659103608000},"page":"77-89","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Resting-State Functional Connectivity Differences Following Experimental Manipulation of the Orbitofrontal Cortex in Two Directions via Theta-Burst Stimulation"],"prefix":"10.1177","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7590-4325","authenticated-orcid":false,"given":"Rebecca B.","family":"Price","sequence":"first","affiliation":[{"name":"Department of Psychiatry, University of Pittsburgh"},{"name":"Department of Psychology, University of Pittsburgh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Ferrarelli","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Pittsburgh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colleen","family":"Hanlon","sequence":"additional","affiliation":[{"name":"Department of Cancer Biology, Wake Forest University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire M.","family":"Gillan","sequence":"additional","affiliation":[{"name":"Department of Psychology, Trinity College Dublin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Pittsburgh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greg J.","family":"Siegle","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Pittsburgh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meredith L.","family":"Wallace","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Pittsburgh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marlee","family":"Renard","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Pittsburgh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Kaskie","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Pittsburgh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Degutis","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Pittsburgh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Wears","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Pittsburgh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Pittsburgh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manivel","family":"Rengasamy","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Pittsburgh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne E.","family":"Ahmari","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Pittsburgh"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,7,29]]},"reference":[{"key":"bibr1-21677026221103136","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2015.11.009"},{"key":"bibr2-21677026221103136","doi-asserted-by":"publisher","DOI":"10.1126\/science.1234733"},{"key":"bibr3-21677026221103136","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"bibr4-21677026221103136","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci10050255"},{"key":"bibr5-21677026221103136","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2019.18101180"},{"key":"bibr6-21677026221103136","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2016.01.008"},{"key":"bibr7-21677026221103136","doi-asserted-by":"publisher","DOI":"10.1016\/j.janxdis.2011.10.001"},{"key":"bibr8-21677026221103136","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2017.11.004"},{"key":"bibr9-21677026221103136","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2015.292"},{"key":"bibr10-21677026221103136","doi-asserted-by":"publisher","DOI":"10.1093\/epirev\/mxn011"},{"key":"bibr11-21677026221103136","doi-asserted-by":"publisher","DOI":"10.1037\/1040-3590.14.4.485"},{"key":"bibr12-21677026221103136","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2014.14040525"},{"key":"bibr13-21677026221103136","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2013.02.002"},{"key":"bibr14-21677026221103136","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2015.12.033"},{"key":"bibr15-21677026221103136","doi-asserted-by":"publisher","DOI":"10.31887\/DCNS.2016.18.1\/shaber"},{"key":"bibr16-21677026221103136","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2015.02.053"},{"key":"bibr17-21677026221103136","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2017.03.039"},{"key":"bibr18-21677026221103136","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2018.07.002"},{"key":"bibr19-21677026221103136","doi-asserted-by":"publisher","DOI":"10.1186\/1743-0003-6-7"},{"key":"bibr20-21677026221103136","doi-asserted-by":"publisher","DOI":"10.1016\/0013-4694(58)90053-1"},{"key":"bibr21-21677026221103136","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0257-12.2012"},{"key":"bibr22-21677026221103136","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2019.00317"},{"key":"bibr23-21677026221103136","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2006.12.003"},{"key":"bibr24-21677026221103136","doi-asserted-by":"publisher","DOI":"10.1159\/000289003"},{"key":"bibr25-21677026221103136","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3999(01)00215-X"},{"key":"bibr26-21677026221103136","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.25170"},{"key":"bibr27-21677026221103136","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1301725110"},{"key":"bibr28-21677026221103136","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awu109"},{"key":"bibr29-21677026221103136","doi-asserted-by":"publisher","DOI":"10.1097\/00004691-200208000-00007"},{"key":"bibr30-21677026221103136","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2013.00463"},{"key":"bibr31-21677026221103136","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2014.62"},{"key":"bibr32-21677026221103136","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/10.3.206"},{"key":"bibr33-21677026221103136","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0789-4"},{"key":"bibr34-21677026221103136","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2015.10.017"},{"key":"bibr35-21677026221103136","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3746"},{"key":"bibr36-21677026221103136","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2019.18101160"},{"key":"bibr37-21677026221103136","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.20900"},{"key":"bibr38-21677026221103136","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-019-0615-x"},{"key":"bibr39-21677026221103136","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2020.20060821"},{"key":"bibr40-21677026221103136","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2010.01.008"},{"key":"bibr41-21677026221103136","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2017.06.048"},{"key":"bibr42-21677026221103136","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.67065"},{"key":"bibr43-21677026221103136","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2015.02.001"},{"key":"bibr44-21677026221103136","doi-asserted-by":"publisher","DOI":"10.4088\/PCC.08m00663"},{"key":"bibr45-21677026221103136","doi-asserted-by":"publisher","DOI":"10.1007\/s11920-008-0048-8"},{"key":"bibr46-21677026221103136","doi-asserted-by":"publisher","DOI":"10.1016\/S0193-953X(05)70181-7"},{"key":"bibr47-21677026221103136","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2020.134871"},{"key":"bibr48-21677026221103136","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2008.09.004"},{"key":"bibr49-21677026221103136","doi-asserted-by":"publisher","DOI":"10.1007\/s10548-008-0067-0"},{"key":"bibr50-21677026221103136","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2004.07.008"},{"key":"bibr51-21677026221103136","doi-asserted-by":"publisher","DOI":"10.1037\/a0018492"},{"key":"bibr52-21677026221103136","doi-asserted-by":"publisher","DOI":"10.1111\/nep.13709"},{"key":"bibr53-21677026221103136","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2020.06.017"},{"key":"bibr54-21677026221103136","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2018.09.004"},{"key":"bibr55-21677026221103136","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(15)00579-9"},{"key":"bibr56-21677026221103136","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2008.04.012"}],"container-title":["Clinical Psychological Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/21677026221103136","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/21677026221103136","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/21677026221103136","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:41:48Z","timestamp":1777394508000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/21677026221103136"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,29]]},"references-count":56,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10.1177\/21677026221103136"],"URL":"https:\/\/doi.org\/10.1177\/21677026221103136","relation":{},"ISSN":["2167-7026","2167-7034"],"issn-type":[{"value":"2167-7026","type":"print"},{"value":"2167-7034","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,29]]}}}