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Although racial-ethnic discrimination is known to be linked with depression, there is limited understanding of how individual differences in brain development contribute to this process. Drawing on the framework of adolescent neurobiological susceptibility, in this study, we examined the moderating role of hippocampal volume in the longitudinal association between racial-ethnic discrimination and adolescent depression. Using longitudinal data of racial-ethnic minority youths from the Adolescent Brain Cognitive Development Study (\n                    <jats:italic toggle=\"yes\">N<\/jats:italic>\n                    = 5,061; age:\n                    <jats:italic toggle=\"yes\">M<\/jats:italic>\n                    = 9.93 years; 52% female), we found that racial-ethnic discrimination was associated with adolescents\u2019 increased depression 2 years later. A larger left hippocampal volume amplified the link between discrimination and depression. These findings highlight the detrimental role of racial-ethnic discrimination on adolescents\u2019 psychological well-being and suggest that hippocampal volume may serve as a neurobiological marker of susceptibility, amplifying the negative impact of racial-ethnic discrimination among racial-ethnic minority youths.\n                  <\/jats:p>","DOI":"10.1177\/21677026251409754","type":"journal-article","created":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T04:11:07Z","timestamp":1770869467000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Hippocampal Volume Moderates the Link Between Racial-Ethnic Discrimination and Early Adolescent Depression"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3390-2513","authenticated-orcid":false,"given":"Shanting","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Psychology, University of Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2869-7845","authenticated-orcid":false,"given":"Beiming","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Education and Social Policy, Northwestern University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7817-724X","authenticated-orcid":false,"given":"Zeix","family":"Zhou","sequence":"additional","affiliation":[{"name":"Human Development and Family Science, University of Texas at Austin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa","family":"Vargas","sequence":"additional","affiliation":[{"name":"Department of Psychology, Harvard University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yichen","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Psychology, Cornell University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. Jeanie","family":"Santaularia Gomez","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, University of Washington"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emma K.","family":"Adam","sequence":"additional","affiliation":[{"name":"School of Education and Social Policy, Northwestern University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0122-9507","authenticated-orcid":false,"given":"Claudia M.","family":"Haase","sequence":"additional","affiliation":[{"name":"School of Education and Social Policy, Northwestern University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6173-8100","authenticated-orcid":false,"given":"Yang","family":"Qu","sequence":"additional","affiliation":[{"name":"School of Education and Social Policy, Northwestern University"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,2,11]]},"reference":[{"key":"e_1_3_3_2_1","unstructured":"ABCD Human Subjects Study. 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