{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T18:18:58Z","timestamp":1777659538897,"version":"3.51.4"},"reference-count":31,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2021,1,7]],"date-time":"2021-01-07T00:00:00Z","timestamp":1609977600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Global Spine Journal"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:sec>\n                    <jats:title>Study design:<\/jats:title>\n                    <jats:p>Preclinical ovine model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To assess the in vivo efficacy and safety of the P-15\u2009L bone graft substitute and compare its performance to autologous iliac crest bone graft (ICBG) for lumbar interbody fusion indications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Thirty skeletally mature sheep underwent lumbar interbody fusion surgery. Half of the sheep received autologous ICBG and the other half the peptide enhanced bone graft substitute (P-15\u2009L). Following termination at 1, 3, and 6 months after surgery, the operated segments were analyzed using micro computed tomography (\u00b5CT), histology, and destructive mechanical testing. Additional systemic health monitoring was performed for the P-15\u2009L group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>One month after surgery, there was only minor evidence of bone remodeling and residual graft material could be clearly observed within the cage. There was active bone remodeling between 1 and 3 months after surgery. At 3 months after surgery significantly denser and stiffer bone was found in the P-15\u2009L group, whereas at 6 months, P-15\u2009L and ICBG gave similar fusion results. The P-15\u2009L bone graft substitute did not have any adverse effects on systemic health.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The drug device combination P-15\u2009L was demonstrated to be effective and save for lumbar interbody fusion as evidenced by this ovine model. Compared to autologous ICBG, P-15\u2009L seems to expedite bone formation and remodeling but in the longer-term fusion results were similar.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/2192568220979839","type":"journal-article","created":{"date-parts":[[2021,1,13]],"date-time":"2021-01-13T18:54:54Z","timestamp":1610564094000},"page":"1330-1337","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Peptide Enhanced Bone Graft Substitute Presents Improved Short-Term Increase in Bone Volume and Construct Stiffness Compared to Iliac Crest Autologous Bone in an Ovine Lumbar Interbody Fusion Model"],"prefix":"10.1177","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7306-0758","authenticated-orcid":false,"given":"Arjan C. Y.","family":"Loenen","sequence":"first","affiliation":[{"name":"Laboratory for Experimental Orthopaedics, Department of Orthopaedic Surgery, CAPHRI, Maastricht University Medical Centre, Maastricht, the Netherlands"},{"name":"Orthopaedic Biomechanics, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerome","family":"Connor","sequence":"additional","affiliation":[{"name":"Cerapedics, Inc, Westminster, CO, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott","family":"Johnson","sequence":"additional","affiliation":[{"name":"Cerapedics, Inc, Westminster, CO, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine","family":"Davis","sequence":"additional","affiliation":[{"name":"Cerapedics, Inc, Westminster, CO, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nolan","family":"Hannigan","sequence":"additional","affiliation":[{"name":"Cerapedics, Inc, Westminster, CO, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tristan","family":"Barnes","sequence":"additional","affiliation":[{"name":"Cerapedics, Inc, Westminster, CO, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacobus J.","family":"Arts","sequence":"additional","affiliation":[{"name":"Laboratory for Experimental Orthopaedics, Department of Orthopaedic Surgery, CAPHRI, Maastricht University Medical Centre, Maastricht, the Netherlands"},{"name":"Orthopaedic Biomechanics, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bert","family":"van Rietbergen","sequence":"additional","affiliation":[{"name":"Laboratory for Experimental Orthopaedics, Department of 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