{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T02:19:48Z","timestamp":1793413188984,"version":"4.5.0"},"reference-count":37,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2022,2,23]],"date-time":"2022-02-23T00:00:00Z","timestamp":1645574400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Canerector Foundation"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Global Spine Journal"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>Systematic review.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Ehlers-Danlos Syndrome (EDS) comprises a spectrum of connective tissue disorders, which may be associated with cranio-cervical instability (CCI). There is a lack of consensus on diagnostic imaging parameters, indications, and outcomes of surgical treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This systematic review analyses the literature on diagnostic methods and\/or criteria for CCI, screening the databases Ovid Medline, Embase, Cochrane Library, and PubMed. Articles were included based on the PRISMA guidelines and assessed using the Newcastle-Ottawa Quality Assessment Scale (NOS) and according to their evidence level.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Sixteen articles, including 78 surgical patients, met the inclusion criteria. The main diagnostic measures for CCI were dynamic x-rays and CT imaging. Ten different radiographic parameters were reported, of which 4 were the most frequently applied for surgical decision-making: the clivo-axial angle (CXA), the Harris measurement, the Grabb\u2013Mapstone\u2013Oakes measurement, and the angular displacement of C1 to C2. The evidence level ranged between III and V and the article quality between 4 and 8 out of 9 stars on the NOS Scale.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>There is a lack of high quality, prospective evidence regarding the evaluation of suspected CCI in patients with EDS. Based on our systematic review, we recommend that the CXA, Harris measurement, Grabb\u2013Mapstone\u2013Oakes measurement, and the angular displacement of C1 to C2 be used to evaluate suspected CCI in EDS patients. Surgical fixation of suspected CCI should only be performed in cases with clear radiographic presence of instability and concordant symptoms\/signs. Consensus-based guidelines and care pathways are required.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/21925682211068520","type":"journal-article","created":{"date-parts":[[2022,2,23]],"date-time":"2022-02-23T10:49:30Z","timestamp":1645613370000},"page":"1862-1871","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":37,"title":["Craniocervical Instability in Ehlers-Danlos Syndrome\u2014A Systematic Review of Diagnostic and Surgical Treatment Criteria"],"prefix":"10.1177","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8027-0569","authenticated-orcid":false,"given":"Laura-Nanna","family":"Lohkamp","sequence":"first","affiliation":[{"name":"Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, ON, Canada"},{"name":"Division of Neurosurgery, Spinal Program, Krembil Nuroscience Centre, Toronto Western Hospital, University Health Network, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8939-2690","authenticated-orcid":false,"given":"Nandan","family":"Marathe","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, ON, Canada"},{"name":"Division of Neurosurgery, Spinal Program, Krembil Nuroscience Centre, Toronto Western Hospital, University Health Network, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5722-6364","authenticated-orcid":false,"given":"Michael G.","family":"Fehlings","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, ON, Canada"},{"name":"Division of Neurosurgery, Spinal Program, Krembil Nuroscience Centre, Toronto Western Hospital, University Health Network, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,2,23]]},"reference":[{"key":"bibr1-21925682211068520","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.220"},{"key":"bibr2-21925682211068520","first-page":"190","volume":"13","author":"Castori M","year":"2014","journal-title":"Iran J Neurol"},{"key":"bibr3-21925682211068520","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320290316"},{"key":"bibr4-21925682211068520","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.31552"},{"key":"bibr5-21925682211068520","first-page":"601","volume":"9","author":"Nagashima C","year":"1981","journal-title":"Noshinkeigeka"},{"key":"bibr6-21925682211068520","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.31549"},{"key":"bibr7-21925682211068520","first-page":"2152","volume":"22","author":"Halko GJ","year":"1995","journal-title":"J Rheumatol"},{"key":"bibr8-21925682211068520","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2019.09.046"},{"key":"bibr9-21925682211068520","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.40507"},{"key":"bibr10-21925682211068520","doi-asserted-by":"publisher","DOI":"10.3171\/spi-07\/12\/601"},{"key":"bibr11-21925682211068520","doi-asserted-by":"publisher","DOI":"10.1007\/s10143-018-01070-4"},{"key":"bibr12-21925682211068520","doi-asserted-by":"publisher","DOI":"10.4103\/jcvjs.JCVJS_166_20"},{"key":"bibr13-21925682211068520","doi-asserted-by":"publisher","DOI":"10.4172\/2165-7939.1000299"},{"key":"bibr14-21925682211068520","doi-asserted-by":"publisher","DOI":"10.1080\/02688697.2017.1386282"},{"key":"bibr15-21925682211068520","unstructured":"Wells GA, Shea B, O\u2019Connell D, et al. 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