{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T12:45:25Z","timestamp":1782132325096,"version":"3.54.5"},"reference-count":40,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2021,2,22]],"date-time":"2021-02-22T00:00:00Z","timestamp":1613952000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Global Spine Journal"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:sec>\n                    <jats:title>Study Design:<\/jats:title>\n                    <jats:p>Retrospective cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>We aimed to evaluate the safety and validity of posterior vertebral column resection (pVCR) for severe thoracolumbar kyphosis (TLK) in the achondroplasia (ACH) patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Seven ACH patients (male: female = 6:1) who underwent pVCR procedures due to severe TLK from December 2008 to December 2017 in the authors\u2019 hospital were included in this retrospective study. Their mean follow-up duration was 67 \u00b1 35 months. Their clinical characteristics, radiologic characteristics, surgical characteristics and surgical complications were reviewed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A total of 8 vertebrae were removed with an average of 5 \u00b1 2 levels of decompression and 9 \u00b1 2 segments instrumented. The mean correction rates of TLKs and the main curves were 73 \u00b1 15% and 87 \u00b1 6%, respectively. Five patients (71%) had preoperative neurological symptoms with a mean Japanese Orthopedic Association (JOA) score of 8 \u00b1 3 points. Their neurological functions were all improved, with a recovery rate of 78 \u00b1 32% for the JOA score at the last follow-up. Four patients (57%) suffered from surgical complications, including rod breakages (43%), neurological complications (28%), dural tears (14%), cerebrospinal fluid leaks (14%) and proximal junction kyphosis (14%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>pVCR can offer a good correction for TLK and improve neurological function with extensive laminectomies in ACH patients. But the morbidity of surgical complications is relatively high. Therefore, it is a reserved surgical option for severe TLK in ACH patients by experienced spinal surgeons, especially with apical markedly hypoplastic vertebrae.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/2192568221989291","type":"journal-article","created":{"date-parts":[[2021,2,22]],"date-time":"2021-02-22T04:25:25Z","timestamp":1613967925000},"page":"1804-1813","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Posterior Vertebral Column Resection (pVCR) for Severe Thoracolumbar Kyphosis in Patients With Achondroplasia"],"prefix":"10.1177","volume":"12","author":[{"given":"Hai","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery, Peking Union Medical College Hospital (PUMCH), Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengru","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Peking Union Medical College Hospital (PUMCH), Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Peking Union Medical College Hospital (PUMCH), Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shujie","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Peking Union Medical College Hospital (PUMCH), Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guixing","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Peking Union Medical College Hospital (PUMCH), Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3129-5190","authenticated-orcid":false,"given":"Jianguo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Peking Union Medical College Hospital (PUMCH), Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,2,22]]},"reference":[{"key":"bibr1-2192568221989291","first-page":"296","volume":"1","author":"Parrott MJ","year":"1878","journal-title":"Bull Soc Anthropol"},{"key":"bibr2-2192568221989291","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-018-0972-6"},{"key":"bibr3-2192568221989291","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.16.2.140"},{"key":"bibr4-2192568221989291","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.32485"},{"key":"bibr5-2192568221989291","volume-title":"GeneReviews((R))","author":"Pauli RM","year":"1993"},{"key":"bibr6-2192568221989291","doi-asserted-by":"publisher","DOI":"10.1007\/s11832-011-0378-7"},{"key":"bibr7-2192568221989291","doi-asserted-by":"publisher","DOI":"10.1016\/j.jspd.2015.08.003"},{"key":"bibr8-2192568221989291","doi-asserted-by":"publisher","DOI":"10.1111\/cge.13542"},{"key":"bibr9-2192568221989291","first-page":"283","volume":"48","author":"Lonstein JE","year":"1988","journal-title":"Basic Life Sci"},{"key":"bibr10-2192568221989291","doi-asserted-by":"publisher","DOI":"10.1007\/s00586-003-0595-y"},{"key":"bibr11-2192568221989291","doi-asserted-by":"publisher","DOI":"10.3171\/foc.2003.14.1.5"},{"key":"bibr12-2192568221989291","first-page":"865","volume":"2","author":"MacLennan A","year":"1922","journal-title":"Br Med J"},{"key":"bibr13-2192568221989291","first-page":"502","volume":"11","author":"Bradford D","year":"1987","journal-title":"Orthop Trans"},{"key":"bibr14-2192568221989291","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-200211010-00012"},{"key":"bibr15-2192568221989291","doi-asserted-by":"publisher","DOI":"10.1097\/01.brs.0000229262.87720.9b"},{"key":"bibr16-2192568221989291","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000008983"},{"issue":"3","key":"bibr17-2192568221989291","first-page":"251","volume":"99","author":"Miyakoshi N","year":"2003","journal-title":"J Neurosurg"},{"key":"bibr18-2192568221989291","doi-asserted-by":"crossref","unstructured":"Tucker S. Expert\u2019s comment concerning grand rounds case entitled \u201cThe natural history of thoracolumbar kyphosis in achondroplasia\u201d by Ahmed M, El-Makhy M, Grevitt M (Eur Spine J; 2016: https:\/\/doi.org\/10.1007\/s00586-016-4861-1). 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