{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T18:21:04Z","timestamp":1777659664692,"version":"3.51.4"},"reference-count":28,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2023,11,18]],"date-time":"2023-11-18T00:00:00Z","timestamp":1700265600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2023,11,18]],"date-time":"2023-11-18T00:00:00Z","timestamp":1700265600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Global Spine Journal"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:sec>\n                    <jats:title>Study design<\/jats:title>\n                    <jats:p>Clinical study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Our work was aimed at exploring the expression and clinical significance of microRNA-138-5p (miR-138-5p) and Transforming Growth Factor-beta 3 (TGF-\u03b23) in peripheral blood of patients with ankylosing spondylitis (AS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Forty-seven patients with AS were selected as the AS group, and the staging of the enrolled AS patients was based on the BASDAI score: &lt;4 points were classified as the stable stage (stable group) and \u22654 points were classified as the active stage (active group). Forty-seven cases were selected from the same period of healthy physical examination in our hospital as the control group. miR-138-5p and TGF-\u03b23 levels and disease activity factors in peripheral blood were measured in all patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Compared to healthy subjects, reduced miR-138-5p levels and increased TGF-\u03b23 levels were found in AS patient. Even more, level of miR-138-5p was decreased and level of TGF-\u03b23 was found to be increased in active disease stage of AS in comparison to inactive disease. Correlation analysis disclosed that miR-138-5p expression in peripheral blood of AS patients was negatively correlated with TGF-\u03b23, HLA-B27, ESR, CRP, and BASDAI; serum TGF-\u03b23 was positively correlated with HLA-B27, ESR, CRP, and BASDAI. The ROC curve analysis disclosed that miR-138-5p and TGF-\u03b23 had certain diagnostic value for AS, and the combined detection could improve the clinical diagnostic capability of this disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>miR-138-5p and TGF-\u03b23 in peripheral blood of AS patients are potential biological markers for the diagnosis of AS and are expected to be new clinical diagnostic indicators.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/21925682231209626","type":"journal-article","created":{"date-parts":[[2023,11,18]],"date-time":"2023-11-18T09:37:10Z","timestamp":1700300230000},"page":"742-748","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Expression and Clinical Significance of microRNA-138-5p and TGF-\u03b23 in Peripheral Blood of Patients With Ankylosing Spondylitis"],"prefix":"10.1177","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-8702-9759","authenticated-orcid":false,"given":"Yonghong","family":"Cheng","sequence":"first","affiliation":[{"name":"The Third Affiliated Hospital of Anhui Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhidong","family":"Zhang","sequence":"additional","affiliation":[{"name":"The Third Affiliated Hospital of Anhui Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,11,18]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185X.14080"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.30313"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/cei.12670"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000003325"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.26500"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2010.81"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.2174\/1381612825666190905163046"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2014.05.089"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12253-019-00633-0"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1080\/10520295.2017.1401663"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.22698"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.2741\/s266"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.reuma.2014.01.009"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26195732"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.25559"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2018.05.003"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-014-0489-6"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri2708"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtauto.2020.100050"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1139\/bcb-2020-0163"},{"issue":"9","key":"e_1_3_3_22_2","first-page":"2177","article-title":"miR-138 suppressed the progression of osteoarthritis mainly through targeting p65","volume":"21","author":"Wei ZJ","year":"2017","unstructured":"Wei ZJ, Liu J, Qin J. miR-138 suppressed the progression of osteoarthritis mainly through targeting p65. 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