{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T18:04:31Z","timestamp":1777658671236,"version":"3.51.4"},"reference-count":54,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T00:00:00Z","timestamp":1751414400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T00:00:00Z","timestamp":1751414400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Global Spine Journal"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>Prospective genetic cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      Adolescent idiopathic scoliosis (AIS) is a common spinal disorder affecting individuals aged 10-18 years without other underlying health conditions. This study aimed to examine the potential etiologic association between AIS and polymorphisms in the\n                      <jats:italic toggle=\"yes\">LBX1<\/jats:italic>\n                      (rs11190870, rs625039, rs11598564),\n                      <jats:italic toggle=\"yes\">TIMP2<\/jats:italic>\n                      (rs8179090),\n                      <jats:italic toggle=\"yes\">GPR126<\/jats:italic>\n                      (rs6570507), and\n                      <jats:italic toggle=\"yes\">CHD7<\/jats:italic>\n                      (rs121434341) genes in Turkish patients. Additionally, the relationships of these polymorphisms with sex, age, age at diagnosis, and Cobb angle were evaluated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The study included 301 individuals: 201 patients with AIS (aged 10-18 years, Cobb angle \u226510\u00b0, no genetic disorders or related diseases), and 100 healthy controls (aged 10-18 years, no scoliosis diagnosis). The study analyzed rs625039, rs11598564, rs6570507, rs121434341, rs11190870, and rs8179090 polymorphisms in patients with AIS and controls using RT-PCR, confirmed the SNP regions through DNA sequencing, and performed statistical analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In this study, the rs11190870 polymorphism of the\n                      <jats:italic toggle=\"yes\">LBX1<\/jats:italic>\n                      gene demonstrated a statistically significant difference between patients with AIS and the control group (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .001), but no significance was observed for the other polymorphisms analyzed. Sex-based analysis revealed a significant association for the\n                      <jats:italic toggle=\"yes\">LBX1<\/jats:italic>\n                      rs11598564 polymorphism, with a higher frequency observed in females (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .029); no significant differences were identified for the other polymorphisms in terms of sex. The rs8179090 and rs121434341 polymorphisms, previously associated with AIS in other populations, showed no statistically significant association in the present study cohort.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      The\n                      <jats:italic toggle=\"yes\">LBX1<\/jats:italic>\n                      gene rs11190870 polymorphism was found to be associated with AIS in Turkish patients.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/21925682251356933","type":"journal-article","created":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T14:03:16Z","timestamp":1751464996000},"page":"617-627","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Investigation of\n                    <i>LBX1, TIMP2, GPR126<\/i>\n                    and\n                    <i>CHD7<\/i>\n                    Gene Polymorphisms in Adolescent Idiopathic Scoliosis Patients"],"prefix":"10.1177","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2535-5310","authenticated-orcid":false,"given":"Erkan","family":"Bilgin","sequence":"first","affiliation":[{"name":"Bursa Uludag University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0910-4258","authenticated-orcid":false,"given":"Havva","family":"Tezcan Unlu","sequence":"additional","affiliation":[{"name":"Bursa Uludag University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3820-424X","authenticated-orcid":false,"given":"Gulsah","family":"Cecener","sequence":"additional","affiliation":[{"name":"Bursa Uludag University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huri Sema","family":"Aymelek","sequence":"additional","affiliation":[{"name":"Bursa City Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0433-1918","authenticated-orcid":false,"given":"Yucel","family":"Bilgin","sequence":"additional","affiliation":[{"name":"Bursa Uludag University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8679-6008","authenticated-orcid":false,"given":"Burak","family":"Akesen","sequence":"additional","affiliation":[{"name":"Bursa Uludag University"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,7,2]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00586-009-1247-7"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2474-13-259"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.3238\/arztebl.2010.0875"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-197860020-00005"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/1748-7161-1-2"},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-199710000-00006"},{"key":"e_1_3_6_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/jmedgenet-2018-105877"},{"key":"e_1_3_6_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/16.4.537"},{"key":"e_1_3_6_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddq571"},{"key":"e_1_3_6_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.BRS.0000083235.74593.49"},{"key":"e_1_3_6_12_2","doi-asserted-by":"publisher","DOI":"10.4184\/asj.2016.10.6.1163"},{"key":"e_1_3_6_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.974"},{"key":"e_1_3_6_14_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.127.2.437"},{"key":"e_1_3_6_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0b013e3181891751"},{"key":"e_1_3_6_16_2","doi-asserted-by":"publisher","DOI":"10.1186\/1748-7161-4-24"},{"key":"e_1_3_6_17_2","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620x.85b7.14046"},{"key":"e_1_3_6_18_2","doi-asserted-by":"publisher","DOI":"10.1186\/1748-7161-3-8"},{"key":"e_1_3_6_19_2","doi-asserted-by":"publisher","DOI":"10.2741\/2024"},{"key":"e_1_3_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2003.12.003"},{"key":"e_1_3_6_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0167-4838(99)00279-4"},{"issue":"2","key":"e_1_3_6_22_2","first-page":"111","article-title":"Tissue inhibitors of metalloproteinases: structure, regulation and biological functions","volume":"74","author":"Gomez DE","year":"1997","unstructured":"Gomez DE, Alonso DF, Yoshiji H, Thorgeirsson UP. 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