{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T22:08:04Z","timestamp":1793743684966,"version":"4.6.1"},"reference-count":21,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T00:00:00Z","timestamp":1755129600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T00:00:00Z","timestamp":1755129600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Global Spine Journal"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:sec>\n                    <jats:title>Study design<\/jats:title>\n                    <jats:p>Retrospective Multicenter Comparative Study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The population\u2019s aging is progressively increasing the number of elderly patients on antiplatelet medications undergoing lumbar fusion procedures. Lateral lumbar interbody fusion (LLIF) has demonstrated valuable clinical and radiological advantages compared to conventional posterior fusion procedures in treating degenerative spine disorders. This study aims to evaluate the safety of continuing antiplatelet drug administration in the perioperative time for patients undergoing single- or multiple-level LLIF for degenerative lumbar disorders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This is a multicenter retrospective study on the safety and efficacy of continuing acetyl salicylic acid therapy in patients undergoing single- or multiple-level LLIF. Age, gender, body mass index (BMI), smoking status, presence of diabetes mellitus, and relevant comorbidities were considered as independent variables in influencing clinical-radiological and surgical outcomes and complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 421 levels were operated on the 332 patients included in the study. The mean introperative blood loss was 42.3 \u00b1 27.4\u00a0cc in the CG, and 47.2 \u00b1 31.8\u00a0cc in the TG (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.12). The drainage collected volume in the postoperative 24\u00a0h was 21.2 \u00b1 13.9\u00a0cc in the CG, and 23.6 \u00b1 11.9\u00a0cc in the TG (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.11). No significant differences were reported in clinical, neurological, and radiological outcomes between the 2 groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our results suggest that acetylsalicylic acid discontinuation in patients undergoing single- or multiple-level XLIF for degenerative spine disorders is not supported, according to similar blood loss and complications\u2019 rate between patients discontinuing and those continuing antiplatelet drugs. Further dedicated clinical trials are needed to confirm our results.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/21925682251370256","type":"journal-article","created":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T12:02:42Z","timestamp":1755172962000},"page":"985-991","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Safety of Acetylsalicylic Acid Continuation in Mono- and Multi-Level Lateral Lumbar Interbody Fusion: Multicenter Comparative Study on 332 Patients"],"prefix":"10.1177","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5110-8386","authenticated-orcid":false,"given":"Luca","family":"Ricciardi","sequence":"first","affiliation":[{"name":"Sapienza Universit\u00e0 di Roma"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sokol","family":"Trungu","sequence":"additional","affiliation":[{"name":"Pia Fondazione di Culto e Religione Cardinal G. 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