{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T07:58:37Z","timestamp":1793692717103,"version":"4.5.1"},"reference-count":33,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T00:00:00Z","timestamp":1761350400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T00:00:00Z","timestamp":1761350400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Global Spine Journal"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>Retrospective Cohort Study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study evaluates the association between preoperative GLP-1 RA (glucagon-like-peptide-1 receptor antagonist) use and postoperative outcomes in patients undergoing lumbar fusion surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      TriNetX database identified patients undergoing lumbar fusion within 20\u00a0years using Current Procedural Terminology (CPT). Patients were categorized by GLP-1 RA use within 1\u00a0year preoperatively. 1:1 propensity score match (PSM) balanced demographics and comorbidities including race\/ethnicity, age, gender, hypertension, diabetes, obesity, nicotine dependence, sleep apnea, ischemic heart diseases, chronic kidney disease, acute kidney failure, mood disorders, asthma, chronic obstructive pulmonary disease, heart failure, alcohol dependence, anemia, and vitamin D deficiency. Primary outcomes were 1-year complications postoperatively. Chi-square analysis, risk ratios (RRs), 95% confidence intervals (CI), and\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      -values were calculated; significance was\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      4331 patients using preoperative GLP-1 RA were propensity score-matched with 179,268 controls without GLP-1 RA use, resulting in 4331 patients in each cohort after matching. At 1\u00a0year, GLP-1 RA users had significant reductions in DVT (1.4% vs 2.3%, RR = 0.64, 95% CI [0.464-0.883],\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.0061), PE (1.1% vs 1.6%, RR = 0.689, 95% CI [0.476-0.997],\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.0466), sepsis (4.0% vs 5.0%, RR = 0.811, 95% CI [0.66-0.995],\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.0447), all-cause mortality (2.1% vs 4.6%, RR = 0.46, 95% CI [0.36-0.589],\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.0001), pneumonia (2.4% vs 3.3%, RR = 0.716, 95% CI [0.548-0.936],\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.0139), and pseudoarthrosis (8.9% vs 13.8%, RR = 0.642, 95% CI [0.564-0.732],\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.0001) compared to non-users.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Preoperative GLP-1 RA use is associated with a reduction in postoperative complications following lumbar fusion surgery. Further research is necessary to elucidate the underlying mechanisms and evaluate long-term outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/21925682251391693","type":"journal-article","created":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T17:51:57Z","timestamp":1761414717000},"page":"1889-1897","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Association Between Preoperative GLP-1 Receptor Analog Use and Postoperative Complications and Mortality Following Lumbar Fusion Surgery"],"prefix":"10.1177","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-7725-8984","authenticated-orcid":false,"given":"Ahad A.","family":"Kesaria","sequence":"first","affiliation":[{"name":"The University of Texas Medical Branch"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-0073-3210","authenticated-orcid":false,"given":"Farhad A.","family":"Marzook","sequence":"additional","affiliation":[{"name":"The University of Texas Medical Branch"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-2344-2959","authenticated-orcid":false,"given":"James M.","family":"Glover","sequence":"additional","affiliation":[{"name":"The University of Texas Medical Branch"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pouya","family":"Alijanipour","sequence":"additional","affiliation":[{"name":"The University of Texas Medical Branch"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,10,25]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2010.11.041"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.21037\/jss-20-492"},{"key":"e_1_3_5_4_2","unstructured":"Rajaee SS Bae HW Kanim LEA Delamarter RB. 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American society of anesthesiologists consensus-based guidance on preoperative management of patients (adults and children) on glucagon-like peptide-1 (GLP-1) receptor agonists. https:\/\/www.asahq.org\/about-asa\/newsroom\/news-releases\/2023\/06\/american-society-of-anesthesiologists-consensus-based-guidance-on-preoperative. Accessed April 5 2025."},{"key":"e_1_3_5_34_2","unstructured":"Most patients can continue diabetes weight loss GLP-1 drugs before surgery those at highest risk for GI problems should follow liquid diet before procedure. https:\/\/www.asahq.org\/about-asa\/newsroom\/news-releases\/2024\/10\/new-multi-society-glp-1-guidance. 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