{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T15:58:04Z","timestamp":1780934284605,"version":"3.54.1"},"reference-count":22,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T00:00:00Z","timestamp":1766361600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T00:00:00Z","timestamp":1766361600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Peking University Third Hospital Talent Incubation Fund","award":["Y77477-03"],"award-info":[{"award-number":["Y77477-03"]}]},{"name":"The Peking University Third Hospital Clinical Cohort Project","award":["BYSYDL2022009"],"award-info":[{"award-number":["BYSYDL2022009"]}]},{"name":"Natural Science Foundation of Beijing Municipality","award":["7252164"],"award-info":[{"award-number":["7252164"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Global Spine Journal"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>Prospective cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Postoperative cerebrospinal fluid leakage (CSFL) is a common complication following thoracic spinal stenosis (TSS) surgery. This study aimed to evaluate the therapeutic effects of different fluid supplementation strategies on intracranial hypotension symptoms (IHS) caused by CSFL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients who developed CSFL after TSS surgery at a single center over a 3-year period were prospectively enrolled. All patients received standardized postural and drainage management. In addition, they were administered either low-sodium or high-sodium solution supplementation alongside standard medications. The incidence and severity of IHS and changes of blood electrolyte levels were compared between the two groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The incidence of IHS in low-sodium group is 57.5%, and in high-sodium group is 40% (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .117). Although, there was no statistically significant difference in the improvement of IHS between the two fluid supplementation strategies. However, statistical differences in blood electrolyte levels were observed. On postoperative days 2 and 3, serum sodium levels were significantly lower in the low-sodium group (139.9 \u00b1 2.08 vs 141.1 \u00b1 3.1,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .022; 140.0 \u00b1 3.0 vs 141.25 \u00b1 3.85,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .034).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>While high-sodium fluid supplementation tended to reduce the incidence of IHS following CSFL, the difference compared to low-sodium fluids was not statistically significant. Nonetheless, the observed differences in electrolyte level of sodium suggest a potential physiological impact. Further studies with larger sample sizes are needed to confirm these findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/21925682251407966","type":"journal-article","created":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T09:19:43Z","timestamp":1766395183000},"page":"2410-2415","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Fluid Supplementation Therapy for Cerebrospinal Fluid Leakage Secondary to Thoracic Spinal Decompression Surgery\u2014A Prospective Cohort Study"],"prefix":"10.1177","volume":"16","author":[{"given":"Zixuan","family":"Xu","sequence":"first","affiliation":[{"name":"Peking University Third Hospital"},{"name":"Peking University Third Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanghui","family":"Chen","sequence":"additional","affiliation":[{"name":"Peking University Third Hospital"},{"name":"Peking University Third 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