{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T08:14:05Z","timestamp":1783757645897,"version":"3.55.0"},"reference-count":23,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2025,12,27]],"date-time":"2025-12-27T00:00:00Z","timestamp":1766793600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,12,27]],"date-time":"2025-12-27T00:00:00Z","timestamp":1766793600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Global Spine Journal"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>Prospective Study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Degenerative lumbar central spinal stenosis (DLCCS) commonly affects the elderly, causing back and leg pain that often necessitates surgical intervention. Perioperative tranexamic acid (TXA) effectively reduces blood loss in lumbar instrumented fusion surgeries. Its effectiveness in elderly patients undergoing posterolateral lumbar instrumented fusion and posterior decompression for DLCCS remains insufficiently investigated. This study aims to evaluate the potential benefits of TXA in these surgical interventions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>170 patients with DLCCS that underwent posterolateral lumbar instrumented fusion with posterior decompression at two consecutive vertebral levels were included. Patients were divided into two groups: Group A (87) without intravenous TXA and Group B (83) with intravenous TXA 30 minutes preoperatively. Outcomes included intraoperative blood loss, postoperative drainage, transfusion rates, surgical duration, initiation of mobilization and hospital stay.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      No significant differences were found in patients\u2019 baseline demographics. Surgical duration was significantly shorter in the TXA group (103.6 \u00b1 9.8\u00a0min vs 128.6 \u00b1 8.2\u00a0min,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001). Intraoperative blood loss was lower in the TXA group (462.7 \u00b1 92.0\u00a0mL vs 864.4 \u00b1 157.0\u00a0mL,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001), as was postoperative drainage (85.2 \u00b1 47.6\u00a0mL vs 207.4 \u00b1 153.5\u00a0mL,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001). Postoperative transfusion was required in 3 TXA patients vs 27 in the non-TXA group (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001). TXA patients mobilized earlier (7.4 \u00b1 3.4 hours vs 12.1 \u00b1 8.1 hours,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001) and had a shorter hospital stay (2.1 \u00b1 0.4 days vs 2.6 \u00b1 0.9 days,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Preoperative TXA administration in this spinal surgery improved surgical and postoperative outcomes and should be considered more.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/21925682251414056","type":"journal-article","created":{"date-parts":[[2025,12,27]],"date-time":"2025-12-27T15:29:36Z","timestamp":1766849376000},"page":"2740-2748","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Tranexamic Acid in Posterolateral Lumbar Instrumented Fusion for Central Spinal Stenosis: A Clinical Study"],"prefix":"10.1177","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6276-2447","authenticated-orcid":false,"given":"Stylianos","family":"Kapetanakis","sequence":"first","affiliation":[{"name":"Interbalkan European Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikail","family":"Chatzivasiliadis","sequence":"additional","affiliation":[{"name":"Interbalkan European Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgios","family":"Charitoudis","sequence":"additional","affiliation":[{"name":"Interbalkan European Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos","family":"Gkantsinikoudis","sequence":"additional","affiliation":[{"name":"Interbalkan European Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christos","family":"Cholevas","sequence":"additional","affiliation":[{"name":"Aristotle University of Thessaloniki"},{"name":"Aristotle University of Thessaloniki AHEPA Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8935-5566","authenticated-orcid":false,"given":"Constantinos","family":"Chaniotakis","sequence":"additional","affiliation":[{"name":"Interbalkan European Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,12,27]]},"reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2022.5921"},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","DOI":"10.21037\/amj.2017.04.13"},{"key":"e_1_3_7_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0b013e3182955989"},{"key":"e_1_3_7_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0b013e3181d359bd"},{"key":"e_1_3_7_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-022-05510-7"},{"key":"e_1_3_7_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00586-020-06424-5"},{"key":"e_1_3_7_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13018-020-1552-8"},{"key":"e_1_3_7_9_2","doi-asserted-by":"publisher","DOI":"10.36076\/ppj.2018.4.383"},{"key":"e_1_3_7_10_2","doi-asserted-by":"publisher","DOI":"10.4184\/asj.2018.12.3.484"},{"key":"e_1_3_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.spinee.2015.01.013"},{"key":"e_1_3_7_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-27307-3"},{"key":"e_1_3_7_13_2","doi-asserted-by":"publisher","DOI":"10.3171\/2024.2.SPINE23779"},{"key":"e_1_3_7_14_2","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.53498"},{"key":"e_1_3_7_15_2","doi-asserted-by":"publisher","DOI":"10.2147\/ORR.S321881"},{"key":"e_1_3_7_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/BSD.0000000000000808"},{"issue":"6","key":"e_1_3_7_17_2","first-page":"719","article-title":"Transfusion of blood and blood products: indications and complications","volume":"83","author":"Sharma S","year":"2011","unstructured":"Sharma S, Sharma P, Tyler LN. Transfusion of blood and blood products: indications and complications. 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